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Efficacy of Neoadjuvant Chemotherapy with Capecitabine plus Oxaliplatin in the Treatment of Locally Advanced Sigmoid Colon Cancer Invading the Urinary Bladder: A Report of Three Cases
Joint Authors
Takenami, Tsutomu
Takahashi, Jun
Tamaki, Sawako
Maemoto, Ryo
Fukuda, Rintaro
Ishikawa, Hideki
Kakizawa, Nao
Hasegawa, Fumi
Kikugawa, Rina
Miyakura, Yasuyuki
Suzuki, Koichi
Tanaka, Akira
Rikiyama, Toshiki
Tsujinaka, Shingo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
We herein present three cases of locally advanced colon cancer (LACC) invading the urinary bladder, in whom combined neoadjuvant chemotherapy with surgical intervention was effective in disease control and preserving urinary function.
Case Presentation.
Before neoadjuvant chemotherapy, all three cases underwent loop transverse colostomy for symptomatic colonic obstruction.
Case 1: after 6 courses of capecitabine plus oxaliplatin (CAPOX), we performed sigmoid colectomy and partial resection of the bladder.
The histological examination revealed pathological complete response (pCR).
The final diagnosis was ypStage 0 (ypT0ypN0M0).
Case 2: after 13 courses of CAPOX plus bevacizumab, we performed Hartmann’s operation with partial resection of the bladder.
The histological examination revealed pCR.
The final diagnosis was ypStage 0 (ypT0ypN0M0).
Case 3: after 6 courses of chemotherapy with CAPOX plus bevacizumab, we performed sigmoid colectomy and partial resection of the bladder.
The pathological response was grade 1a according to the Japanese Classification of Colorectal Carcinoma.
The final diagnosis was ypStage IIC (ypT4bypN0M0).
All three cases underwent capecitabine-based adjuvant chemotherapy after radical surgery and patients are alive without recurrence.
Conclusion.
Neoadjuvant chemotherapy with CAPOX with or without bevacizumab followed by radical surgery could be an effective treatment option for LACC invading the urinary bladder.
American Psychological Association (APA)
Takenami, Tsutomu& Tsujinaka, Shingo& Takahashi, Jun& Tamaki, Sawako& Maemoto, Ryo& Fukuda, Rintaro…[et al.]. 2019. Efficacy of Neoadjuvant Chemotherapy with Capecitabine plus Oxaliplatin in the Treatment of Locally Advanced Sigmoid Colon Cancer Invading the Urinary Bladder: A Report of Three Cases. Case Reports in Surgery،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1145079
Modern Language Association (MLA)
Takenami, Tsutomu…[et al.]. Efficacy of Neoadjuvant Chemotherapy with Capecitabine plus Oxaliplatin in the Treatment of Locally Advanced Sigmoid Colon Cancer Invading the Urinary Bladder: A Report of Three Cases. Case Reports in Surgery No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1145079
American Medical Association (AMA)
Takenami, Tsutomu& Tsujinaka, Shingo& Takahashi, Jun& Tamaki, Sawako& Maemoto, Ryo& Fukuda, Rintaro…[et al.]. Efficacy of Neoadjuvant Chemotherapy with Capecitabine plus Oxaliplatin in the Treatment of Locally Advanced Sigmoid Colon Cancer Invading the Urinary Bladder: A Report of Three Cases. Case Reports in Surgery. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1145079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145079