Adrenal Oncocytic Neoplasm with Paradoxical Loss of Important Mitochondrial Steroidogenic Protein: The 18 kDA Translocator Protein
Joint Authors
Ruiz-Cordero, Roberto
Gupta, Alia
Jayakumar, Arumugam R.
Nielsen, Gunnlaugur Petur
Jorda, Merce
Ciancio, Gaetano
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The adrenal glands produce a variety of hormones that play a key role in the regulation of blood pressure, electrolyte homeostasis, metabolism, immune system suppression, and the body’s physiologic response to stress.
Adrenal neoplasms can be asymptomatic or can overproduce certain hormones that lead to different clinical manifestations.
Oncocytic adrenal neoplasms are infrequent tumors that arise from cells in the adrenal cortex and display a characteristic increase in the number of cytoplasmic mitochondria.
Since the rate-limiting step in steroidogenesis includes the transport of cholesterol across the mitochondrial membranes, in part carried out by the 18-kDa translocator protein (TSPO), we assessed the expression of TSPO in a case of adrenal oncocytic neoplasm using residual adrenal gland of the patient as internal control.
We observed a significant loss of TSPO immunofluorescence expression in the adrenal oncocytic tumor cells when compared to adjacent normal adrenal tissue.
We further confirmed this finding by employing Western blot analysis to semiquantify TSPO expression in tumor and normal adrenal cells.
Our findings could suggest a potential role of TSPO in the tumorigenesis of this case of adrenocortical oncocytic neoplasm.
American Psychological Association (APA)
Ruiz-Cordero, Roberto& Gupta, Alia& Jayakumar, Arumugam R.& Ciancio, Gaetano& Nielsen, Gunnlaugur Petur& Jorda, Merce. 2017. Adrenal Oncocytic Neoplasm with Paradoxical Loss of Important Mitochondrial Steroidogenic Protein: The 18 kDA Translocator Protein. Case Reports in Endocrinology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1145142
Modern Language Association (MLA)
Ruiz-Cordero, Roberto…[et al.]. Adrenal Oncocytic Neoplasm with Paradoxical Loss of Important Mitochondrial Steroidogenic Protein: The 18 kDA Translocator Protein. Case Reports in Endocrinology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1145142
American Medical Association (AMA)
Ruiz-Cordero, Roberto& Gupta, Alia& Jayakumar, Arumugam R.& Ciancio, Gaetano& Nielsen, Gunnlaugur Petur& Jorda, Merce. Adrenal Oncocytic Neoplasm with Paradoxical Loss of Important Mitochondrial Steroidogenic Protein: The 18 kDA Translocator Protein. Case Reports in Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1145142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145142