The Adjustment of Covariates in Cox’s Model under Case-Cohort Design
Joint Authors
Rong, Guocai
Tang, Luwei
Deng, Lifeng
Li, Qing
Luo, Wenting
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-24
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Case-cohort design is a biased sampling method.
Due to its cost-effective and theoretical significance, this design has extensive application value in many large cohort studies.
The case-cohort data includes a subcohort sampled randomly from the entire cohort and all the failed subjects outside the subcohort.
In this paper, the adjustment for the distorted covariates is considered to case-cohort data in Cox’s model.
According to the existing adjustable methods of distorted covariates for linear and nonlinear models, we propose estimating the distorting functions by nonparametrically regressing the distorted covariates on the distorting factors; then, the estimators for the parameters are obtained using the estimated covariates.
The proof of consistency and being asymptotically normal is completed.
For calculating the maximum likelihood estimates of the regression coefficients subject in Cox’s model, a minorization-maximization (MM) algorithm is developed.
Simulation studies are performed to compare the estimations with the covariates undistorted, distorted, and adjusted to illustrate the proposed methods.
American Psychological Association (APA)
Rong, Guocai& Tang, Luwei& Luo, Wenting& Li, Qing& Deng, Lifeng. 2020. The Adjustment of Covariates in Cox’s Model under Case-Cohort Design. Complexity،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1145147
Modern Language Association (MLA)
Rong, Guocai…[et al.]. The Adjustment of Covariates in Cox’s Model under Case-Cohort Design. Complexity No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1145147
American Medical Association (AMA)
Rong, Guocai& Tang, Luwei& Luo, Wenting& Li, Qing& Deng, Lifeng. The Adjustment of Covariates in Cox’s Model under Case-Cohort Design. Complexity. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1145147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145147