De Novo Atypical Haemolytic Uremic Syndrome after Kidney Transplantation
Joint Authors
Aydin, Selda
Devresse, Arnaud
de Meyer, Martine
Dahan, Karin
Kanaan, Nada
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-14
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
De novo thrombotic microangiopathy (TMA) can occur after kidney transplantation.
An abnormality of the alternative pathway of complement must be suspected and searched for, even in presence of a secondary cause.
We report the case of a 23-year-old female patient who was transplanted with a kidney from her mother for end-stage renal disease secondary to Hinman syndrome.
Early after transplantation, she presented with 2 episodes of severe pyelonephritis, associated with acute kidney dysfunction and biological and histological features of TMA.
Investigations of the alternative pathway of the complement system revealed atypical haemolytic uremic syndrome secondary to complement factor I mutation, associated with mutations in CD46 and complement factor H related protein genes.
Plasma exchanges followed by eculizumab injections allowed improvement of kidney function without, however, normalization of creatinine.
American Psychological Association (APA)
Devresse, Arnaud& de Meyer, Martine& Aydin, Selda& Dahan, Karin& Kanaan, Nada. 2018. De Novo Atypical Haemolytic Uremic Syndrome after Kidney Transplantation. Case Reports in Nephrology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1145181
Modern Language Association (MLA)
Devresse, Arnaud…[et al.]. De Novo Atypical Haemolytic Uremic Syndrome after Kidney Transplantation. Case Reports in Nephrology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1145181
American Medical Association (AMA)
Devresse, Arnaud& de Meyer, Martine& Aydin, Selda& Dahan, Karin& Kanaan, Nada. De Novo Atypical Haemolytic Uremic Syndrome after Kidney Transplantation. Case Reports in Nephrology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1145181
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145181