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Clinical Relapses of Atypical HUS on Eculizumab: Clinical Gap for Monitoring and Individualised Therapy
Joint Authors
Awan, Atif
Teoh, Chia Wei
Gorman, Kathleen Mary
Lynch, Bryan
Goodship, Timothy H. J.
Dolan, Niamh Marie
Riordan, Michael
Waldron, Mary
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-06
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Atypical hemolytic uremic syndrome (aHUS) is caused by dysregulation of the complement system.
A humanised anti-C5 monoclonal antibody (eculizumab) is available for the treatment of aHUS.
We present the first description of atypical HUS in a child with a coexistent diagnosis of a POL-III leukodystrophy.
On standard eculizumab dosing regime, there was evidence of ongoing C5 cleavage and clinical relapses when immunologically challenged.
Eculizumab is an effective therapy for aHUS, but the recommended doses may not be adequate for all patients, highlighting the need for ongoing efforts to develop a strategy for monitoring of treatment efficacy and potential individualisation of therapy.
American Psychological Association (APA)
Teoh, Chia Wei& Gorman, Kathleen Mary& Lynch, Bryan& Goodship, Timothy H. J.& Dolan, Niamh Marie& Waldron, Mary…[et al.]. 2018. Clinical Relapses of Atypical HUS on Eculizumab: Clinical Gap for Monitoring and Individualised Therapy. Case Reports in Nephrology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1145185
Modern Language Association (MLA)
Teoh, Chia Wei…[et al.]. Clinical Relapses of Atypical HUS on Eculizumab: Clinical Gap for Monitoring and Individualised Therapy. Case Reports in Nephrology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1145185
American Medical Association (AMA)
Teoh, Chia Wei& Gorman, Kathleen Mary& Lynch, Bryan& Goodship, Timothy H. J.& Dolan, Niamh Marie& Waldron, Mary…[et al.]. Clinical Relapses of Atypical HUS on Eculizumab: Clinical Gap for Monitoring and Individualised Therapy. Case Reports in Nephrology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1145185
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145185