Acute Renal Failure due to a Tobramycin and Vancomycin Spacer in Revision Two-Staged Knee Arthroplasty
Joint Authors
Patel, Ronak A.
Baker, Hayden P.
Smith, Sara B.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Two-stage revision total knee arthroplasty (TKA) is the standard of care for prosthetic joint infections.
The first stage involves removal of the infected prosthesis and placement of an antibiotic impregnated cement spacer; following a period ranging from 4 weeks to 6 months, the spacer is then removed and replaced with a permanent prosthesis.
The advantage to this approach is that antibiotic impregnated spacers provide supratherapeutic levels in the joint without toxic accumulation in serum.
However, it remains important for physicians and pharmacists to be aware of antibiotic associated complications in knee revisions.
We present a case of a two-stage revision total knee arthroplasty in which a cement antibiotic spacer caused acute renal failure and ultimately resulted in persistent chronic kidney disease without hemodialysis at 2 months’ follow-up.
Our case reports the third highest serum tobramycin (13.7 mcg/ml) and second highest serum creatinine (8.62 mg/dl) for patients experiencing ARF due to an antibiotic spacer in two-stage revision TKA.
American Psychological Association (APA)
Patel, Ronak A.& Baker, Hayden P.& Smith, Sara B.. 2018. Acute Renal Failure due to a Tobramycin and Vancomycin Spacer in Revision Two-Staged Knee Arthroplasty. Case Reports in Nephrology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1145227
Modern Language Association (MLA)
Patel, Ronak A.…[et al.]. Acute Renal Failure due to a Tobramycin and Vancomycin Spacer in Revision Two-Staged Knee Arthroplasty. Case Reports in Nephrology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1145227
American Medical Association (AMA)
Patel, Ronak A.& Baker, Hayden P.& Smith, Sara B.. Acute Renal Failure due to a Tobramycin and Vancomycin Spacer in Revision Two-Staged Knee Arthroplasty. Case Reports in Nephrology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1145227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145227