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Anticoagulant Related Nephropathy Induced by Dabigatran
Joint Authors
Muruve, Daniel A.
Sharfuddin, Nazia
Nourbakhsh, Mahra
Box, Alan
Benediktsson, Hallgrimur
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We describe a case of biopsy-proven dabigatran related nephropathy in a patient without underlying IgA nephropathy.
To date, dabigatran related nephropathy was only reported in patients with concurrent or undiagnosed IgA nephropathy, suggesting that it may predispose patients to dabigatran associated injury.
The patient is an 81-year-old woman with multiple medical comorbidities, including nonvalvular atrial fibrillation, who was anticoagulated with dabigatran.
She presented to hospital with acute kidney injury in the setting of volume overload.
Her estimated glomerular filtration rate decreased from a baseline of 57 mL/min/1.73 m2 to 4 mL/min/1.73 m2, necessitating hemodialysis.
Renal ultrasound findings, fractional excretion of sodium, and urinalysis suggested acute kidney injury.
Renal biopsy showed acute tubular injury, tubular red blood cell casts, and an absence of active glomerulonephritis, similar to the pathological findings of warfarin related nephropathy.
A diagnosis of anticoagulant related nephropathy secondary to dabigatran was therefore established.
This case demonstrates that dabigatran, like warfarin, may increase tubular bleeding risk in patients, irrespective of underlying kidney or glomerular disease.
American Psychological Association (APA)
Sharfuddin, Nazia& Nourbakhsh, Mahra& Box, Alan& Benediktsson, Hallgrimur& Muruve, Daniel A.. 2018. Anticoagulant Related Nephropathy Induced by Dabigatran. Case Reports in Nephrology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1145234
Modern Language Association (MLA)
Sharfuddin, Nazia…[et al.]. Anticoagulant Related Nephropathy Induced by Dabigatran. Case Reports in Nephrology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1145234
American Medical Association (AMA)
Sharfuddin, Nazia& Nourbakhsh, Mahra& Box, Alan& Benediktsson, Hallgrimur& Muruve, Daniel A.. Anticoagulant Related Nephropathy Induced by Dabigatran. Case Reports in Nephrology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1145234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145234