Rifampicin in Nontuberculous Mycobacterial Infections: Acute Kidney Injury with Hemoglobin Casts
Joint Authors
Polenakovik, Hari
Kora, Rishi
Brodsky, Sergey V.
Agra, Dean
Nadasdy, Tibor
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Rifampicin is a key component of multidrug regimens not only for tuberculosis, but also nontuberculous mycobacterial infections (NTM) which are on the rise worldwide.
Knowledge of the toxicity profile is important.
Hepatotoxicity is a well-known side effect of Rifampicin necessitating regular liver function monitoring during therapy.
Acute kidney injury (AKI) is a relatively rare complication, usually resulting from allergic interstitial nephritis (AIN).
Rifampicin-induced intravascular hemolysis resulting in hemoglobinuria and AKI is even more uncommon, especially in Western countries with low prevalence of mycobacterial infections.
Rifampicin-induced antibodies are implicated and this complication preferentially occurs during intermittent drug treatment protocols or when Rifampicin is restarted after a long drug-free interval.
Awareness of this drug complication and its unique timing is important especially among emergency room physicians where patients with AKI may first present.
It is equally important for nephrologists and pathologists.
We describe one such case with detailed clinical course of the patient and interesting biopsy findings of ATN with intratubular hemoglobin casts.
American Psychological Association (APA)
Kora, Rishi& Brodsky, Sergey V.& Nadasdy, Tibor& Agra, Dean& Polenakovik, Hari. 2018. Rifampicin in Nontuberculous Mycobacterial Infections: Acute Kidney Injury with Hemoglobin Casts. Case Reports in Nephrology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1145257
Modern Language Association (MLA)
Kora, Rishi…[et al.]. Rifampicin in Nontuberculous Mycobacterial Infections: Acute Kidney Injury with Hemoglobin Casts. Case Reports in Nephrology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1145257
American Medical Association (AMA)
Kora, Rishi& Brodsky, Sergey V.& Nadasdy, Tibor& Agra, Dean& Polenakovik, Hari. Rifampicin in Nontuberculous Mycobacterial Infections: Acute Kidney Injury with Hemoglobin Casts. Case Reports in Nephrology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1145257
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145257