Leptomeningeal and Intraparenchymal Blood Barrier Disruption in a MOG-IgG-Positive Patient
Joint Authors
Jarius, Sven
Asgari, Nasrin
Reindl, Markus
Wuerfel, Jens
Mohseni, Seyed Hamidreza
Skejoe, Hanne Pernille Bro
Paul, Friedemann
Source
Case Reports in Neurological Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-09
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Background.
Recently, pathogenic serum immunoglobulin G (IgG) autoantibodies to myelin oligodendrocyte glycoprotein (MOG) have been detected in a subgroup of patients with central nervous system (CNS) demyelination, including in patients with myelitis.
Relatively little is known so far about leptomeningeal involvement in MOG-IgG-positive myelitis.
Findings.
We report the case of a 30-year-old previously healthy woman presenting with longitudinally extensive transverse myelitis and tetraparesis, in whom both the leptomeningeal barrier and the blood-brain barrier (BBB) were altered, as demonstrated by gadolinium-enhanced MRI during relapse.
Blood samples taken at onset and four years later were retrospectively found positive for MOG-IgG.
Conclusion.
Our findings demonstrate that spinal leptomeningeal enhancement (LME) can occur in MOG-IgG-positive encephalomyelitis (EM) and may accompany intraparenchymal BBB breakdown.
American Psychological Association (APA)
Mohseni, Seyed Hamidreza& Skejoe, Hanne Pernille Bro& Wuerfel, Jens& Paul, Friedemann& Reindl, Markus& Jarius, Sven…[et al.]. 2018. Leptomeningeal and Intraparenchymal Blood Barrier Disruption in a MOG-IgG-Positive Patient. Case Reports in Neurological Medicine،Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1145309
Modern Language Association (MLA)
Mohseni, Seyed Hamidreza…[et al.]. Leptomeningeal and Intraparenchymal Blood Barrier Disruption in a MOG-IgG-Positive Patient. Case Reports in Neurological Medicine No. 2018 (2018), pp.1-3.
https://search.emarefa.net/detail/BIM-1145309
American Medical Association (AMA)
Mohseni, Seyed Hamidreza& Skejoe, Hanne Pernille Bro& Wuerfel, Jens& Paul, Friedemann& Reindl, Markus& Jarius, Sven…[et al.]. Leptomeningeal and Intraparenchymal Blood Barrier Disruption in a MOG-IgG-Positive Patient. Case Reports in Neurological Medicine. 2018. Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1145309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145309