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Nivolumab-Induced Autoimmune Encephalitis in Two Patients with Lung Adenocarcinoma
Joint Authors
Shah, Suma
Dunn-Pirio, Anastasie
Luedke, Matthew
Morgenlander, Joel
Skeen, Mark
Eckstein, Christopher
Source
Case Reports in Neurological Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-04
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Immune checkpoint inhibitors have improved patient survival outcomes in a variety of advanced malignancies.
However, they can cause a number of immune-related adverse effects (irAEs) through lymphocyte dysregulation.
Central nervous system (CNS) irAEs are rare, but as the number of indications for checkpoint inhibitors increases, there has been emergence of CNS immune-mediated disease among cancer patients.
Given the relatively recent recognition of checkpoint inhibitor CNS irAEs, there is no standard treatment, and prognosis is variable.
Therefore, there is a great need for further study of checkpoint inhibitor-induced CNS irAEs.
Here, we present two unique cases of nivolumab-induced autoimmune encephalitis in patients with non-small cell lung cancer and review the available literature.
American Psychological Association (APA)
Shah, Suma& Dunn-Pirio, Anastasie& Luedke, Matthew& Morgenlander, Joel& Skeen, Mark& Eckstein, Christopher. 2018. Nivolumab-Induced Autoimmune Encephalitis in Two Patients with Lung Adenocarcinoma. Case Reports in Neurological Medicine،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1145351
Modern Language Association (MLA)
Shah, Suma…[et al.]. Nivolumab-Induced Autoimmune Encephalitis in Two Patients with Lung Adenocarcinoma. Case Reports in Neurological Medicine No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1145351
American Medical Association (AMA)
Shah, Suma& Dunn-Pirio, Anastasie& Luedke, Matthew& Morgenlander, Joel& Skeen, Mark& Eckstein, Christopher. Nivolumab-Induced Autoimmune Encephalitis in Two Patients with Lung Adenocarcinoma. Case Reports in Neurological Medicine. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1145351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145351