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Alfa-Fetoprotein-Producing Female Primary Urethral Adenocarcinoma with Neuroendocrine Differentiation
Joint Authors
Akakura, Koichiro
Mitsui, Yozo
Natsuyama, Takao
Uetani, Masato
Ohta, Shigeyuki
Inoue, Masafumi
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-09
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
We report an extremely rare case of an alpha-fetoprotein- (AFP-) producing female primary urethral adenocarcinoma with neuroendocrine differentiation (NED).
The patient was a 65-year-old woman with a 2-year history of urinary frequency and voiding difficulty.
Enhanced computed tomography showed an approximately 3.0×5.0-cm mass around the proximal urethra and bladder neck.
Of examined tumor markers, serum AFP was elevated (48.3 ng/mL), while others including carcinoembryonic antigen were within a normal range.
Transurethral resection of the tumor led to a diagnosis of carcinosarcoma of the urethra, with a radical cystourethrectomy and ileal conduit formation subsequently performed.
The pathological assessment was poorly differentiated adenocarcinoma in the urethra.
Immunostaining showed tumor cells strongly positive for AFP.
In addition, some cancer cells were positive for CD56, chromogranin A, and synaptophysin, indicating focal NED.
The tumor was finally diagnosed as an AFP-producing urethral adenocarcinoma with NED.
Serum AFP was immediately normalized after surgery and no sign of tumor recurrence has been noted 2 years postoperatively.
American Psychological Association (APA)
Natsuyama, Takao& Mitsui, Yozo& Uetani, Masato& Ohta, Shigeyuki& Inoue, Masafumi& Akakura, Koichiro. 2019. Alfa-Fetoprotein-Producing Female Primary Urethral Adenocarcinoma with Neuroendocrine Differentiation. Case Reports in Urology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1145371
Modern Language Association (MLA)
Natsuyama, Takao…[et al.]. Alfa-Fetoprotein-Producing Female Primary Urethral Adenocarcinoma with Neuroendocrine Differentiation. Case Reports in Urology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1145371
American Medical Association (AMA)
Natsuyama, Takao& Mitsui, Yozo& Uetani, Masato& Ohta, Shigeyuki& Inoue, Masafumi& Akakura, Koichiro. Alfa-Fetoprotein-Producing Female Primary Urethral Adenocarcinoma with Neuroendocrine Differentiation. Case Reports in Urology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1145371
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145371