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Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache
Joint Authors
Antonio, Costantini
Massimo, Tiberi
Gianpaolo, Zarletti
Immacolata, Pala Maria
Erika, Trevi
Source
Case Reports in Neurological Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Cluster headache is a rare painful primary disorder occurring in either episodic or chronic patterns.
Several authors found that the hypothalamus, the brain region regulating endocrine function and autonomic system, is involved in the pathophysiology of cluster headache.
Some authors have found in patients affected by this disease abnormality in glucose metabolism.
Considering the role of thiamine in brain function, in energetic metabolism, and in pain modulation, we treated a patient affected by cluster headache with oral high-dose thiamine.
We report a 41-year-old man suffering from primary chronic cluster headache since the age of 15 years.
The patient began oral therapy with high-dose thiamine in December 2016.
Oral thiamine supplementation led to a dramatic improvement of the symptoms.
The therapy was effective in reversing all the symptoms of the disease.
Our observation suggests that a thiamine deficiency due to enzymatic abnormalities or to dysfunction of the circulation of thiamine in the intracellular space could cause a neuronal selective impairment in the centers that are involved in this disease and could have an important role in the pathogenesis of the symptoms of cluster headache.
American Psychological Association (APA)
Antonio, Costantini& Massimo, Tiberi& Gianpaolo, Zarletti& Immacolata, Pala Maria& Erika, Trevi. 2018. Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache. Case Reports in Neurological Medicine،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1145385
Modern Language Association (MLA)
Antonio, Costantini…[et al.]. Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache. Case Reports in Neurological Medicine No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1145385
American Medical Association (AMA)
Antonio, Costantini& Massimo, Tiberi& Gianpaolo, Zarletti& Immacolata, Pala Maria& Erika, Trevi. Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache. Case Reports in Neurological Medicine. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1145385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145385