Brain Complete Response to Cabozantinib prior to Radiation Therapy in Metastatic Renal Cell Carcinoma
Joint Authors
Uche, An
Sila, Chad
Tanoura, Tad
Bhowmick, Neil
Posadas, Edwin
Figlin, Robert
Yeh, James
Gong, Jun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-13
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Cabozantinib represents an established vascular endothelial growth factor- (VEGF-) tyrosine kinase inhibitor (TKI) in the treatment paradigm of metastatic renal cell carcinoma (mRCC).
Its activity in mRCC patients with brain metastases (BMs) has been largely underreported in prospective clinical trials.
We present the unique case of a heavily pretreated mRCC patient with BMs who achieved a brain complete response to cabozantinib prior to receiving radiation therapy.
We end with a literature review and discussion of the biologic rationale and growing evidence supporting the intracranial activity of cabozantinib.
American Psychological Association (APA)
Uche, An& Sila, Chad& Tanoura, Tad& Yeh, James& Bhowmick, Neil& Posadas, Edwin…[et al.]. 2019. Brain Complete Response to Cabozantinib prior to Radiation Therapy in Metastatic Renal Cell Carcinoma. Case Reports in Urology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1145441
Modern Language Association (MLA)
Uche, An…[et al.]. Brain Complete Response to Cabozantinib prior to Radiation Therapy in Metastatic Renal Cell Carcinoma. Case Reports in Urology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1145441
American Medical Association (AMA)
Uche, An& Sila, Chad& Tanoura, Tad& Yeh, James& Bhowmick, Neil& Posadas, Edwin…[et al.]. Brain Complete Response to Cabozantinib prior to Radiation Therapy in Metastatic Renal Cell Carcinoma. Case Reports in Urology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1145441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145441