A Rare Case of Rivaroxaban Causing Delayed Symptomatic Hepatocellular Injury and Hyperbilirubinemia
Joint Authors
Glenn, Keith
Chen, Patrick
Musleh, Mustafa
Pallivi, Rao
Grilliot, Melissa
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-30
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Importance.
As Rivaroxaban has increased in popularity, it has been accompanied with a growing body of evidence displaying its ability to cause drug induced liver injury (DILI).
Observation.
A 74-year-old Caucasian female developed Rivaroxaban DILI two weeks after finishing a 14-day course.
The patient was symptomatic and jaundiced with elevated transaminases and hyperbilirubinemia with normal lab values two months priorly.
Liver biopsies showed mixed inflammatory infiltrate of lymphocytes, neutrophils and eosinophils, rare necrotic hepatocytes, and canalicular and intrahepatocellular cholestasis, all of which are consistent with DILI.
Conclusion and Relevance.
We present this case to add to the growing evidence that Rivaroxaban can be associated with severe, symptomatic liver injury and to ensure physicians are aware of these possible side effects of novel anticoagulants with their increasing use.
American Psychological Association (APA)
Glenn, Keith& Chen, Patrick& Musleh, Mustafa& Pallivi, Rao& Grilliot, Melissa. 2017. A Rare Case of Rivaroxaban Causing Delayed Symptomatic Hepatocellular Injury and Hyperbilirubinemia. Case Reports in Gastrointestinal Medicine،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1145550
Modern Language Association (MLA)
Glenn, Keith…[et al.]. A Rare Case of Rivaroxaban Causing Delayed Symptomatic Hepatocellular Injury and Hyperbilirubinemia. Case Reports in Gastrointestinal Medicine No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1145550
American Medical Association (AMA)
Glenn, Keith& Chen, Patrick& Musleh, Mustafa& Pallivi, Rao& Grilliot, Melissa. A Rare Case of Rivaroxaban Causing Delayed Symptomatic Hepatocellular Injury and Hyperbilirubinemia. Case Reports in Gastrointestinal Medicine. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1145550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145550