Characterization of a Small Supernumerary Marker Chromosome Derived from Xq28 and 14q11.2 Detected Prenatally

Abstract EN

We present the characterization of a case with a small supernumerary marker chromosome (sSMC) detected prenatally derived from Xq28 and 14q11.2 maternal translocation.

A 33-year-old Japanese woman, primigravida, underwent amniocentesis because of fetal growth restriction and fetal structural abnormality at 30 weeks of gestation.

The fetal karyotype was identified as 47,XY,+mar.

Additionally, the single nucleotide polymorphism array analysis revealed copy number gains at Xq28 and 14q11.2.

A male infant, weighing 1,391 g, was delivered at term by cesarean section.

Maternal and paternal karyotypes were 46,X,t(X; 14)(q28; q11) and 46,XY, respectively.

These findings indicated that the sSMC might have originated from chromosome disjunction at a ratio of three to one.

Here we describe a case with an sSMC derived from Xq28 and 14q11.2.

Our findings suggest that this sSMC is most likely pathogenic.

The collection of additional cases may be required.