Prognostic Value of Concomitant Bronchiectasis in Newly Diagnosed Diffuse Panbronchiolitis Patients on a Maintenance Therapy with Macrolides
Joint Authors
Xu, Benyong
Mao, Yanhua
Wan, Xiaoyu
Chen, Jianhui
Ye, Meiping
Zhan, Mengling
Xu, Liyun
Zhao, Lan
Li, Bing
Zhang, Zhemin
Liu, Yang
Chu, Haiqing
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Factors determining the prognosis of diffuse panbronchiolitis (DPB) remain unclear at present.
The objective of this study was to identify the prognostic value of concomitant bronchiectasis in the macrolide treatment efficacy and exacerbation risk in DPB patients.
Methods.
Data of patients initially diagnosed with DPB at the Shanghai Pulmonary Hospital between January 2007 and December 2017 were retrospectively collected and analyzed.
The patients were divided into two groups according to the existence of bronchiectasis.
Clinical manifestations, laboratory findings, microbiological culture results, as well as exacerbation risks and treatment outcomes, were compared between these two groups.
The survival curve and Cox regression analysis models were additionally constructed to further demonstrate the predicting role of bronchiectasis in DPB exacerbation.
Results.
Baseline data revealed more respiratory symptoms, lower body mass index (BMI), and forced expiratory volume in one second (FEV1) as well as increased isolates of Pseudomonas aeruginosa (P.
aeruginosa) in DPB subjects with bronchiectasis than those without.
Furthermore, bronchiectasis was associated with a lower rate of responsiveness to macrolides and increased exacerbation frequency during follow-up.
The survival curve and Cox regression analysis showed that comorbid bronchiectasis was linked to increased time to episode relapse, which remained significant even after controlling for BMI, FEV1, and P.
aeruginosa culture results.
Conclusion.
The coexistence of bronchiectasis predicted a poor outcome of maintenance macrolide therapy and an increased exacerbation risk in DPB subjects, possibly through its impacts on nutritional status, pulmonary function, and P.
aeruginosa infections.
American Psychological Association (APA)
Xu, Benyong& Mao, Yanhua& Wan, Xiaoyu& Chen, Jianhui& Ye, Meiping& Zhan, Mengling…[et al.]. 2019. Prognostic Value of Concomitant Bronchiectasis in Newly Diagnosed Diffuse Panbronchiolitis Patients on a Maintenance Therapy with Macrolides. Canadian Respiratory Journal،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1145726
Modern Language Association (MLA)
Xu, Benyong…[et al.]. Prognostic Value of Concomitant Bronchiectasis in Newly Diagnosed Diffuse Panbronchiolitis Patients on a Maintenance Therapy with Macrolides. Canadian Respiratory Journal No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1145726
American Medical Association (AMA)
Xu, Benyong& Mao, Yanhua& Wan, Xiaoyu& Chen, Jianhui& Ye, Meiping& Zhan, Mengling…[et al.]. Prognostic Value of Concomitant Bronchiectasis in Newly Diagnosed Diffuse Panbronchiolitis Patients on a Maintenance Therapy with Macrolides. Canadian Respiratory Journal. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1145726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145726