Peripheral T-Cell Lymphoma of the Submandibular Salivary Gland as an Unusual Manifestation of Richter’s Syndrome: A Case Report and Literature Review
Joint Authors
Kondratieva, Tatiana T.
Gorodetskiy, Vadim
Probatova, Natalya
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Richter’s syndrome is the development of high-grade non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL).
In most patients with Richter’s syndrome, the high-grade NHL is diffuse large B-cell lymphoma.
Only a small minority of CLL/SLL patients develop T-cell malignancies.
Herein, we describe a 40-year-old male patient presenting with peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) in the submandibular salivary gland, two years after the diagnosis of CLL/SLL.
The PTCL-NOS consisted of small lymphocytes, which complicated diagnosis.
Immunohistochemical, cytological, and molecular studies allowed the correct diagnosis of composite lymphoma (SLL/PTCL-NOS) of the submandibular salivary gland.
The PTCL-NOS had a cytotoxic phenotype and aberrant expression of CD79a.
There was no evidence to suggest that the PTCL-NOS of the submandibular salivary gland developed from an intimately associated submandibular lymph node or by PTCL-NOS dissemination.
A review of the literature and presented case suppose that the PTCLs developed following CLL/SLL have the cytotoxic phenotype and can clinically mimic typical Richter’s syndrome.
American Psychological Association (APA)
Gorodetskiy, Vadim& Probatova, Natalya& Kondratieva, Tatiana T.. 2017. Peripheral T-Cell Lymphoma of the Submandibular Salivary Gland as an Unusual Manifestation of Richter’s Syndrome: A Case Report and Literature Review. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1145736
Modern Language Association (MLA)
Gorodetskiy, Vadim…[et al.]. Peripheral T-Cell Lymphoma of the Submandibular Salivary Gland as an Unusual Manifestation of Richter’s Syndrome: A Case Report and Literature Review. Case Reports in Hematology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1145736
American Medical Association (AMA)
Gorodetskiy, Vadim& Probatova, Natalya& Kondratieva, Tatiana T.. Peripheral T-Cell Lymphoma of the Submandibular Salivary Gland as an Unusual Manifestation of Richter’s Syndrome: A Case Report and Literature Review. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1145736
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145736