Real-World Evidence of Safety and Efficacy of Carboplatin plus Nanoparticle Albumin-Bound Paclitaxel in Patients with Advanced Non-Small-Cell Lung Cancer and Preexisting Interstitial Lung Disease: A Retrospective Study
Joint Authors
Araya, Tomoyuki
Kita, Toshiyuki
Ueda, Tsukasa
Terada, Nanao
Sakai, Tamami
Yamamura, Kenta
Kurokawa, Koji
Uchida, Yuka
Sone, Takashi
Kimura, Hideharu
Kasahara, Kazuo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Standard chemotherapy for advanced non-small-cell lung cancer (NSCLC) with preexisting interstitial lung disease (ILD) has not yet been established.
Although a combination of carboplatin and paclitaxel is most frequently used for patients with advanced NSCLC and ILD, the safety and efficacy of carboplatin plus nanoparticle albumin-bound paclitaxel (nab-paclitaxel) are yet to be elucidated.
Objectives.
This study aimed to evaluate the safety and efficacy of carboplatin plus nab-paclitaxel for advanced NSCLC with ILD.
Methods.
This retrospective study included nine patients with advanced NSCLC and ILD who received carboplatin plus nab-paclitaxel as first-line chemotherapy at the National Hospital Organization Kanazawa Medical Center between April 2013 and December 2017.
The ILD-GAP index was used to evaluate mortality risk of baseline ILD.
Results.
A usual interstitial pneumonia (UIP) pattern of ILD was observed in five (55.6%) patients on their baseline high-resolution computed tomography (HRCT) scans.
The median ILD-GAP index was 4 (range, 1–5), and six (66.7%) patients had ILD-GAP index ≥4.
We observed no ILD exacerbations or chemotherapy-related deaths.
The overall response and disease control rates were 77.8% (95% CI, 40.0–97.2) and 88.9% (95% CI, 51.8–97.2), respectively.
The median progression-free survival and overall survival were 5.8 months (95% CI, 2.1–7.7) and 8.0 months (95% CI, 2.6–16.8), respectively.
Conclusions.
Carboplatin plus nab-paclitaxel showed favorable safety and efficacy in patients who had advanced NSCLC and ILD with a high risk of mortality.
Prospective studies are required to further confirm these results.
American Psychological Association (APA)
Araya, Tomoyuki& Kita, Toshiyuki& Ueda, Tsukasa& Terada, Nanao& Sakai, Tamami& Yamamura, Kenta…[et al.]. 2019. Real-World Evidence of Safety and Efficacy of Carboplatin plus Nanoparticle Albumin-Bound Paclitaxel in Patients with Advanced Non-Small-Cell Lung Cancer and Preexisting Interstitial Lung Disease: A Retrospective Study. Canadian Respiratory Journal،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1145739
Modern Language Association (MLA)
Araya, Tomoyuki…[et al.]. Real-World Evidence of Safety and Efficacy of Carboplatin plus Nanoparticle Albumin-Bound Paclitaxel in Patients with Advanced Non-Small-Cell Lung Cancer and Preexisting Interstitial Lung Disease: A Retrospective Study. Canadian Respiratory Journal No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1145739
American Medical Association (AMA)
Araya, Tomoyuki& Kita, Toshiyuki& Ueda, Tsukasa& Terada, Nanao& Sakai, Tamami& Yamamura, Kenta…[et al.]. Real-World Evidence of Safety and Efficacy of Carboplatin plus Nanoparticle Albumin-Bound Paclitaxel in Patients with Advanced Non-Small-Cell Lung Cancer and Preexisting Interstitial Lung Disease: A Retrospective Study. Canadian Respiratory Journal. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1145739
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145739