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Successful Management of Acquired Hemophilia A Associated with Bullous Pemphigoid: A Case Report and Review of the Literature
Joint Authors
Hermans, Cedric
Lambert, Catherine
Binet, Quentin
Sacré, Laurine
Eeckhoudt, Stéphane
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Acquired hemophilia A (AHA) is a rare condition, due to the spontaneous formation of neutralizing antibodies against endogenous factor VIII.
About half the cases are associated with pregnancy, postpartum, autoimmune diseases, malignancies, or adverse drug reactions.
Symptoms include severe and unexpected bleeding that may prove life-threatening.
Case Study.
We report a case of AHA associated with bullous pemphigoid (BP), a chronic, autoimmune, subepidermal, blistering skin disease.
To our knowledge, this is the 25th documented case of such an association.
Following treatment for less than 3 months consisting of methylprednisolone at decreasing dose levels along with four courses of rituximab (monoclonal antibody directed against the CD20 protein), AHA was completely cured and BP well-controlled.
Conclusions.
This report illustrates a rare association of AHA and BP, supporting the possibility of eradicating the inhibitor with a well-conducted short-term treatment.
American Psychological Association (APA)
Binet, Quentin& Lambert, Catherine& Sacré, Laurine& Eeckhoudt, Stéphane& Hermans, Cedric. 2017. Successful Management of Acquired Hemophilia A Associated with Bullous Pemphigoid: A Case Report and Review of the Literature. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1145779
Modern Language Association (MLA)
Binet, Quentin…[et al.]. Successful Management of Acquired Hemophilia A Associated with Bullous Pemphigoid: A Case Report and Review of the Literature. Case Reports in Hematology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1145779
American Medical Association (AMA)
Binet, Quentin& Lambert, Catherine& Sacré, Laurine& Eeckhoudt, Stéphane& Hermans, Cedric. Successful Management of Acquired Hemophilia A Associated with Bullous Pemphigoid: A Case Report and Review of the Literature. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1145779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145779