Serum Concentrations of OsteogenesisOsteolysis-Related Factors and Micro-RNA Expression in ST-Elevation Myocardial Infarction
Joint Authors
Jadczyk, Tomasz
Francuz, Tomasz
Garczorz, Wojciech
Kimsa-Furdzik, Malgorzata
Dutka, Mieczyslaw
Gaik, Ewa
Syzdol, Marcin
Wanha, Wojciech
Kurzelowski, Radoslaw
Fluder, Joanna
Starek, Zdenek
Gruszczyńska, Katarzyna
Wojakowski, Wojciech
Source
Cardiology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Atherosclerosis and bone metabolism share similar molecular and cellular mechanisms.
This study aims to evaluate (1) serum concentration of osteogenesis/osteolysis factors panel (Dickkopf-related protein 1 (DKK-1), TNF-α, N-terminal atrial natriuretic peptide (NT-proANP), thrombospondin-2 (TSP-2), osteoprotegerin (OPG), osteocalcin (OCN), osteopontin (OPN), fibroblast growth factor 23 (FGF-23), soluble receptor activator of nuclear factor-kappaB ligand (sRANKL), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), proprotein convertase subtilisin/kexin type 9 (PCSK9)), (2) serum expression levels of micro-RNA- (miR-) 24-1 and miR-6802, and (3) assess their correlation with myocardial injury and LV remodeling and function in the acute phase of STEMI and after 3 months.
Methods.
Study enrolled 25 STEMI patients (mean age 55.4 ± 8.96 years).
Blood samples were collected 4 days and 3 months after myocardial infarction.
Serum concentrations of osteogenesis/osteolysis factors were measured using the Luminex assay.
Analysis of miR-24-1, and miR-6802 expression was performed with qPCR.
LV function and remodeling were assessed by MRI during index hospitalization and 3 months later.
Results.
There were no significant differences in serum levels of osteogenesis/osteolysis factors and expression of miR-24-1 and miR-6802 between the acute phase and 3-month follow-up.
The levels were similar in patients with at least ≥5% improvement of LVEF (n = 10) and those without improvement.
There was a negative correlation between the OPG serum level and LVEF during the acute phase of myocardial infarction.
Conclusions.
In STEMI patients, serum concentrations of osteogenesis/osteolysis factors, as well as miR-24-1 and miR-6802 expression, do not change significantly within the 3-month follow-up and are not correlated with LV remodeling and function.
American Psychological Association (APA)
Jadczyk, Tomasz& Francuz, Tomasz& Garczorz, Wojciech& Kimsa-Furdzik, Malgorzata& Dutka, Mieczyslaw& Gaik, Ewa…[et al.]. 2019. Serum Concentrations of OsteogenesisOsteolysis-Related Factors and Micro-RNA Expression in ST-Elevation Myocardial Infarction. Cardiology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1145866
Modern Language Association (MLA)
Jadczyk, Tomasz…[et al.]. Serum Concentrations of OsteogenesisOsteolysis-Related Factors and Micro-RNA Expression in ST-Elevation Myocardial Infarction. Cardiology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1145866
American Medical Association (AMA)
Jadczyk, Tomasz& Francuz, Tomasz& Garczorz, Wojciech& Kimsa-Furdzik, Malgorzata& Dutka, Mieczyslaw& Gaik, Ewa…[et al.]. Serum Concentrations of OsteogenesisOsteolysis-Related Factors and Micro-RNA Expression in ST-Elevation Myocardial Infarction. Cardiology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1145866
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145866