GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents
Joint Authors
Xiong, Qian-Feng
Fan, Shao-Hua
Niu, Yu
Wang, Jing
Zhang, Xin
Chen, Yi-Fan
Shi, Ya-Wei
Zhang, Li-Hui
Li, Xuewen
Source
Cardiology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
GLP-1 is a new type of antidiabetic agent that possesses many beneficial effects.
Although its cardiovascular actions have been widely examined, little is known about GLP-1’s effects on the rat coronary artery (RCA) or about the mechanisms underpinning these effects.
Here, we report that GLP-1 inhibits depolarization- or thromboxane receptor agonist (U46619)-induced RCA contraction in a dosage-dependent manner.
Vasorelaxation was attenuated by denuding the endothelium, L-NAME (nitric oxide synthase inhibitor), and glyburide (KATP channel blocker) but was not affected by indomethacin (cyclooxygenase inhibitor), iberiotoxin [Ca2+-activated K+ channel (KCa) blocker], or 4-aminopyridine (KV channel blocker).
Furthermore, GLP-1 increased outward K+ currents by enhancing the KATP channel in rat coronary arterial smooth muscle cells (RCASMCs).
These results show that GLP-1 is an endothelial-dependent vasospasmolytic agent in the RCA and imply that the relaxant effect is regulated by enhancing KATP rather than KV or KCa currents in RCASMCs.
American Psychological Association (APA)
Xiong, Qian-Feng& Fan, Shao-Hua& Li, Xuewen& Niu, Yu& Wang, Jing& Zhang, Xin…[et al.]. 2019. GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents. Cardiology Research and Practice،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1145890
Modern Language Association (MLA)
Xiong, Qian-Feng…[et al.]. GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents. Cardiology Research and Practice No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1145890
American Medical Association (AMA)
Xiong, Qian-Feng& Fan, Shao-Hua& Li, Xuewen& Niu, Yu& Wang, Jing& Zhang, Xin…[et al.]. GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents. Cardiology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1145890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145890