Severe Cytomegalovirus Reactivation in Patient with Low-Grade Non-Hodgkin’s Lymphoma after Standard Chemotherapy

Joint Authors

Borg, Anton
Modvig, Lena
Boyle, Ciaran
Randall, Katie

Source

Case Reports in Hematology

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-10-22

Country of Publication

Egypt

No. of Pages

3

Main Subjects

Diseases

Abstract EN

Clinically significant cytomegalovirus (CMV) reactivation is not uncommon in patients with severe immunodeficiency secondary to underlying medical disorders or following aggressive immunosuppressive therapy.

However, it is less frequently found in patients with low-grade haematological malignancies after nonintensive chemotherapy.

We treated a patient at our centre for stage IVB follicular lymphoma with standard chemotherapy who successively developed CMV colitis associated with a CMV viral load of >3 million copies/ml.

Four lines of antiviral treatment were necessary to obtain biochemical remission with undetectable CMV levels, with an initially insufficient response to valganciclovir despite therapeutic pre- and posttreatment levels.

Subsequently, our patient also developed an infection with Pneumocystis jirovecii pneumonia (PJP) as further evidence of severe immune compromise.

This case report demonstrates the importance of including investigations for less common sources of infection when confronted with a patient with a low-grade haematological malignancy and a pyrexia of unknown origin.

American Psychological Association (APA)

Modvig, Lena& Boyle, Ciaran& Randall, Katie& Borg, Anton. 2017. Severe Cytomegalovirus Reactivation in Patient with Low-Grade Non-Hodgkin’s Lymphoma after Standard Chemotherapy. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1145909

Modern Language Association (MLA)

Modvig, Lena…[et al.]. Severe Cytomegalovirus Reactivation in Patient with Low-Grade Non-Hodgkin’s Lymphoma after Standard Chemotherapy. Case Reports in Hematology No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1145909

American Medical Association (AMA)

Modvig, Lena& Boyle, Ciaran& Randall, Katie& Borg, Anton. Severe Cytomegalovirus Reactivation in Patient with Low-Grade Non-Hodgkin’s Lymphoma after Standard Chemotherapy. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1145909

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1145909