Extramedullary Relapse in a CML Patient after Allogeneic Stem Cell Transplantation
Joint Authors
Saydam, Guray
Ozsan, Nazan
Yilmaz, Asu Fergun
Soyer, Nur
Cagirgan, Seckin
Gunes, Ajda
Comert, Melda
Sahin, Fahri
Gunel, Nur Selvi
Vural, Filiz
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-21
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Myeloid or granulocytic sarcoma (GS) is a tumoral lesion consisting of immature granulocytic cells.
It is a rare entity during the course of CML patients especially after allogeneic stem cell transplantation (SCT).
Relapse without bone marrow involvement is much rarer.
We report a case of CML patient who relapsed with isolated granulocytic sarcoma after allogeneic SCT during cytogenetic and molecular remission.
28-year-old male was diagnosed as CML and allogeneic SCT was performed because of refractory disease to tyrosine kinase inhibitors.
Complete cytogenetic and molecular response was achieved after allogeneic SCT followed by dasatinib treatment.
Approximately 5 years after the transplantation, very rapidly progressive lesion was documented and diagnosed as GS although he was at molecular and cytogenetic remission.
The patient died during chemotherapy due to sepsis.
GS relapse after allogeneic SCT is a very rare type of relapse in CML patients with molecular and cytogenetic remission.
Since it is a very aggressive disease with a poor prognosis, combined chemoradiotherapies with other possible options like DLI or second allogeneic SCT should be considered as soon as the diagnosis is confirmed.
American Psychological Association (APA)
Yilmaz, Asu Fergun& Soyer, Nur& Ozsan, Nazan& Cagirgan, Seckin& Gunes, Ajda& Comert, Melda…[et al.]. 2017. Extramedullary Relapse in a CML Patient after Allogeneic Stem Cell Transplantation. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1145926
Modern Language Association (MLA)
Yilmaz, Asu Fergun…[et al.]. Extramedullary Relapse in a CML Patient after Allogeneic Stem Cell Transplantation. Case Reports in Hematology No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1145926
American Medical Association (AMA)
Yilmaz, Asu Fergun& Soyer, Nur& Ozsan, Nazan& Cagirgan, Seckin& Gunes, Ajda& Comert, Melda…[et al.]. Extramedullary Relapse in a CML Patient after Allogeneic Stem Cell Transplantation. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1145926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145926