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Paroxysmal Nocturnal Hemoglobinuria in Pregnancy: A Dilemma in Treatment and Thromboprophylaxis
Joint Authors
Murphy, Martina
Wingard, John R.
Patel, Arpan
Unnikrishnan, Athira
Wheeler, Sarah
Richards, Ashley
Egerman, Robert
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-24
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Paroxysmal nocturnal hemoglobinuria (PNH) is a hematologic disorder characterized by an acquired somatic mutation in the phosphatidylinositol glycan class A gene which leads to a higher risk for increased venous and arterial thrombosis.
Current treatment for PNH includes eculizumab.
Pregnant patients who have PNH have higher risk for thrombosis and hemorrhage with both pregnancy and their underlying PNH.
Treatment frequently poses conundrum.
The safety and efficacy of eculizumab during pregnancy and breast feeding have not been extensively studied and contraception has been recommended due to potential for teratogenicity.
We present a case of a patient who was safely on both eculizumab and modest prophylactic anticoagulation for 6 weeks post-partum.
American Psychological Association (APA)
Patel, Arpan& Unnikrishnan, Athira& Murphy, Martina& Egerman, Robert& Wheeler, Sarah& Richards, Ashley…[et al.]. 2017. Paroxysmal Nocturnal Hemoglobinuria in Pregnancy: A Dilemma in Treatment and Thromboprophylaxis. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1145962
Modern Language Association (MLA)
Patel, Arpan…[et al.]. Paroxysmal Nocturnal Hemoglobinuria in Pregnancy: A Dilemma in Treatment and Thromboprophylaxis. Case Reports in Hematology No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1145962
American Medical Association (AMA)
Patel, Arpan& Unnikrishnan, Athira& Murphy, Martina& Egerman, Robert& Wheeler, Sarah& Richards, Ashley…[et al.]. Paroxysmal Nocturnal Hemoglobinuria in Pregnancy: A Dilemma in Treatment and Thromboprophylaxis. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1145962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145962