Large Granular Lymphocytic Leukemia: A Report of Response to Rituximab
Joint Authors
Ibrahim, Uroosa
Parylo, Sara
Kedia, Shiksha
Hussein, Shafinaz
Atallah, Jean Paul
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-18
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Large granular lymphocytic (LGL) leukemia is a rare form of low grade leukemia characterized by large cytotoxic T cells or natural killer cells on morphological examination.
Immunosuppressive therapy is employed as first-line therapy.
Treatment options in refractory cases include the anti-CD52 antibody alemtuzumab and purine analogues.
We report a rare case that responded to the anti-CD20 monoclonal antibody rituximab.
A 77-year-old female presented with complaints of fatigue, fever, and chills of 3 months’ duration.
A CBC showed that pancytopenia with an absolute neutrophil count (ANC) was 0.
Peripheral blood flow cytometry detected increased number of T cell large granular lymphocytes and T cell receptor rearrangement study detected a clonal T cell population.
Bone marrow biopsy showed peripheral T cell lymphoma, most consistent with T-large granulocytic leukemia.
The patient was treated with prednisone and oral cyclophosphamide for four months with no response.
Thereafter, she received four weekly infusions of rituximab with improvement in her blood counts.
A response to rituximab in refractory cases such as ours has been reported and may guide us towards exploring other immune-based therapeutics in this rare disease.
American Psychological Association (APA)
Ibrahim, Uroosa& Parylo, Sara& Kedia, Shiksha& Hussein, Shafinaz& Atallah, Jean Paul. 2017. Large Granular Lymphocytic Leukemia: A Report of Response to Rituximab. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1145994
Modern Language Association (MLA)
Ibrahim, Uroosa…[et al.]. Large Granular Lymphocytic Leukemia: A Report of Response to Rituximab. Case Reports in Hematology No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1145994
American Medical Association (AMA)
Ibrahim, Uroosa& Parylo, Sara& Kedia, Shiksha& Hussein, Shafinaz& Atallah, Jean Paul. Large Granular Lymphocytic Leukemia: A Report of Response to Rituximab. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1145994
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145994