PAX5-Negative Classical Hodgkin Lymphoma: A Case Report of a Rare Entity and Review of the Literature
Joint Authors
Dwyre, Denis M.
Rashidi, Hooman H.
Wang, Huan-You
Vali Khojeini, Elham
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-04
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Classical Hodgkin lymphoma (CHL) is recognized as a B-cell neoplasm arising from germinal center or postgerminal center B-cells.
The hallmark of CHL is the presence of CD30 (+) Hodgkin and Reed-Sternberg (HRS) cells with dim expression of PAX5.
Nearly all of the HRS cells are positive for PAX5.
However, a small minority of HRS cells may lack PAX5 expression, which can cause a diagnostic dilemma.
Herein we describe two cases of PAX5-negative CHL and review of the English literature on this very rare entity.
It is crucial to be aware of this phenomenon, which in some cases may lead to misdiagnosis and may ultimately adversely affect patient’s management.
American Psychological Association (APA)
Vali Khojeini, Elham& Dwyre, Denis M.& Wang, Huan-You& Rashidi, Hooman H.. 2017. PAX5-Negative Classical Hodgkin Lymphoma: A Case Report of a Rare Entity and Review of the Literature. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1145999
Modern Language Association (MLA)
Vali Khojeini, Elham…[et al.]. PAX5-Negative Classical Hodgkin Lymphoma: A Case Report of a Rare Entity and Review of the Literature. Case Reports in Hematology No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1145999
American Medical Association (AMA)
Vali Khojeini, Elham& Dwyre, Denis M.& Wang, Huan-You& Rashidi, Hooman H.. PAX5-Negative Classical Hodgkin Lymphoma: A Case Report of a Rare Entity and Review of the Literature. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1145999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145999