Molecular Profiling: A Case of ZBTB16-RARA Acute Promyelocytic Leukemia
Joint Authors
Kelly, Johanna
Preston, Lisa
Goodyer, Matt
Elhassadi, Ezzat
Hayat, Amjad
Langabeer, Stephen E.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Several variant RARA translocations have been reported in acute promyelocytic leukemia (APL) of which the t(11;17)(q23;q21), which results in a ZBTB16-RARA fusion, is the most widely identified and is largely resistant to therapy with all-trans retinoic acid (ATRA).
The clinical course together with the cytogenetic and molecular characterization of a case of ATRA-unresponsive ZBTB16-RARA APL is described.
Additional mutations potentially cooperating with the translocation fusion product in leukemogenesis have been hitherto unreported in ZBTB16-RARA APL and were sought by application of a next-generation sequencing approach to detect those recurrently found in myeloid malignancies.
This technique identified a solitary, low level mutation in the CEBPA gene.
Molecular profiling of additional mutations may provide a platform to individualise therapeutic management in patients with this rare form of APL.
American Psychological Association (APA)
Langabeer, Stephen E.& Preston, Lisa& Kelly, Johanna& Goodyer, Matt& Elhassadi, Ezzat& Hayat, Amjad. 2017. Molecular Profiling: A Case of ZBTB16-RARA Acute Promyelocytic Leukemia. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146005
Modern Language Association (MLA)
Langabeer, Stephen E.…[et al.]. Molecular Profiling: A Case of ZBTB16-RARA Acute Promyelocytic Leukemia. Case Reports in Hematology No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1146005
American Medical Association (AMA)
Langabeer, Stephen E.& Preston, Lisa& Kelly, Johanna& Goodyer, Matt& Elhassadi, Ezzat& Hayat, Amjad. Molecular Profiling: A Case of ZBTB16-RARA Acute Promyelocytic Leukemia. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146005