Management of Venous Thromboembolism in Patients with Hereditary Antithrombin Deficiency and Pregnancy: Case Report and Review of the Literature
Joint Authors
Refaei, Mohammad
Xing, Lydia
Lim, Wendy
Crowther, Mark
Boonyawat, Kochawan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Hereditary antithrombin deficiency is a thrombogenic disorder associated with a 50–90% lifetime risk of venous thromboembolism (VTE), which is increased during pregnancy and the puerperium in these patients.
We present a case of a woman with antithrombin (AT) deficiency who presented with a VTE despite therapeutic low molecular weight heparin (LMWH).
Though the pregnancy was deemed unviable, further maternal complications were mitigated through the combined use of therapeutic anticoagulation and plasma-derived antithrombin concentrate infusions to normalize her functional antithrombin levels.
Methods.
A review of the literature was conducted for studies on prophylaxis and management of VTE in pregnant patients with hereditary AT deficiency.
The search involved a number of electronic databases, using combinations of keywords as described in the text.
Only English language studies between 1946 and 2015 were included.
Conclusion.
Antithrombin concentrate is indicated in pregnant women with hereditary AT deficiency who develop VTE despite being on therapeutic dose anticoagulation.
Expert opinion suggests AT concentrate should be used concomitantly with therapeutic dose anticoagulation.
However, further high-quality studies on the dose and duration of treatment in the postpartum period are required.
Use of AT concentrate for prophylaxis is controversial and should be based on individual VTE risk stratification.
American Psychological Association (APA)
Refaei, Mohammad& Xing, Lydia& Lim, Wendy& Crowther, Mark& Boonyawat, Kochawan. 2017. Management of Venous Thromboembolism in Patients with Hereditary Antithrombin Deficiency and Pregnancy: Case Report and Review of the Literature. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1146054
Modern Language Association (MLA)
Refaei, Mohammad…[et al.]. Management of Venous Thromboembolism in Patients with Hereditary Antithrombin Deficiency and Pregnancy: Case Report and Review of the Literature. Case Reports in Hematology No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1146054
American Medical Association (AMA)
Refaei, Mohammad& Xing, Lydia& Lim, Wendy& Crowther, Mark& Boonyawat, Kochawan. Management of Venous Thromboembolism in Patients with Hereditary Antithrombin Deficiency and Pregnancy: Case Report and Review of the Literature. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1146054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146054