Phoenix dactylifera Protects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity

Joint Authors

Hassan, Waseem
Ahmad, Fiaz ud Din
Wang, Yuewen
Chao, Xu
Shi, Hailong
Mehboob, Hania

Source

Cardiology Research and Practice

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-12-23

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases

Abstract EN

Doxorubicin (DOX) is an important anticancer drug used widely in the treatment of leukemia and lymphoma.

The suitability of DOX is enhanced by its high therapeutic index, but its potential to cause cardiotoxicity and nephrotoxicity remains a prime concern in anticancer therapeutics.

This study is designed to determine the effect of Phoenix dactylifera extract (PDE) on DOX-induced cardiotoxicity and nephrotoxicity.

Experimental rats were divided into four groups, receiving normal saline 4 ml/kg, DOX alone, and crude extract of PDE at doses of 1 g/kg and 1.5 g/kg in the presence of DOX, respectively, for 21 days.

Cardiac enzymes and serum and urinary sodium and potassium levels were evaluated which were analyzed statistically by using one-way ANOVA.

Subsequently, DOX initiated changes in the level of cardiac markers CK-MB, LDH, and troponin I, which were notably reversed by PDE.

PDE was also effective against serum and urinary sodium and urinary potassium and protected against DOX-induced nephrotoxicity.

Groups treated with different doses of PDE showed marked decrease in levels of cardiac and renal markers.

The study concluded that the PDE extract possesses protective effects against DOX-induced cardiotoxicity and nephrotoxicity.

American Psychological Association (APA)

Wang, Yuewen& Chao, Xu& Ahmad, Fiaz ud Din& Shi, Hailong& Mehboob, Hania& Hassan, Waseem. 2019. Phoenix dactylifera Protects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity. Cardiology Research and Practice،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1146057

Modern Language Association (MLA)

Wang, Yuewen…[et al.]. Phoenix dactylifera Protects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity. Cardiology Research and Practice No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1146057

American Medical Association (AMA)

Wang, Yuewen& Chao, Xu& Ahmad, Fiaz ud Din& Shi, Hailong& Mehboob, Hania& Hassan, Waseem. Phoenix dactylifera Protects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity. Cardiology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1146057

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1146057