Leukodepleted Packed Red Blood Cells Transfusion in Patients Undergoing Major Cardiovascular Surgical Procedure: Systematic Review and Meta-Analysis
Joint Authors
Simancas-Racines, Daniel
Arevalo-Rodriguez, Ingrid
Urrutia, Gerard
Buitrago-Garcia, Diana
Núñez-González, Solange
Martínez-Zapata, María José
Bonfill, Xavier
Hidalgo-Ottolenghi, Ricardo
Madrid, Eva
Source
Cardiology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Leukocytes contained in the allogeneic packed red blood cell (PRBC) are the cause of certain adverse reactions associated with blood transfusion.
Leukoreduction consists of eliminating leukocytes in all blood products below the established safety levels for any patient type.
In this systematic review, we appraise the clinical effectiveness of allogeneic leukodepleted (LD) PRBC transfusion for preventing infections and death in patients undergoing major cardiovascular surgical procedures.
Methods.
We searched randomized controlled trials (RCT), enrolling patients undergoing a major cardiovascular surgical procedure and transfused with LD-PRBC.
Data were extracted, and risk of bias was assessed according to Cochrane guidelines.
In addition, trial sequential analysis (TSA) was used to assess the need of conducting additional trials.
Quality of the evidence was assessed using the GRADE approach.
Results.
Seven studies met the eligibility criteria.
Quality of the evidence was rated as moderate for both outcomes.
The risk ratio for death from any cause comparing the LD-PRBC versus non-LD-PRBC group was 0.69 (CI 95% = 0.53 to 0.90; I2 = 0%).
The risk ratio for infection in the same comparison groups was 0.77 (CI 95% = 0.66 to 0.91; I2 = 0%).
TSA showed a conclusive result in this outcome.
Conclusions.
We found evidence that supports the routine use of leukodepletion in patients undergoing a major cardiovascular surgical procedure requiring PRBC transfusion to prevent death and infection.
In the case of infection, the evidence should be considered sufficient and conclusive and hence indicated that further trials would not be required.
American Psychological Association (APA)
Simancas-Racines, Daniel& Arevalo-Rodriguez, Ingrid& Urrutia, Gerard& Buitrago-Garcia, Diana& Núñez-González, Solange& Martínez-Zapata, María José…[et al.]. 2019. Leukodepleted Packed Red Blood Cells Transfusion in Patients Undergoing Major Cardiovascular Surgical Procedure: Systematic Review and Meta-Analysis. Cardiology Research and Practice،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1146063
Modern Language Association (MLA)
Simancas-Racines, Daniel…[et al.]. Leukodepleted Packed Red Blood Cells Transfusion in Patients Undergoing Major Cardiovascular Surgical Procedure: Systematic Review and Meta-Analysis. Cardiology Research and Practice No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1146063
American Medical Association (AMA)
Simancas-Racines, Daniel& Arevalo-Rodriguez, Ingrid& Urrutia, Gerard& Buitrago-Garcia, Diana& Núñez-González, Solange& Martínez-Zapata, María José…[et al.]. Leukodepleted Packed Red Blood Cells Transfusion in Patients Undergoing Major Cardiovascular Surgical Procedure: Systematic Review and Meta-Analysis. Cardiology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1146063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146063