Severe Aplastic Anemia following Parvovirus B19-Associated Acute Hepatitis
Joint Authors
Furukawa, Masanori
Kaji, Kosuke
Masuda, Hiroyuki
Ozaki, Kuniaki
Asada, Shohei
Koizumi, Aritoshi
Kubo, Takuya
Nishimura, Norihisa
Sawada, Yasuhiko
Takeda, Kosuke
Mashitani, Tsuyoshi
Kubo, Masayuki
Amano, Itsuto
Ootani, Tomoyuki
Murata, Koji
Ann, Tatsuichi
Mitoro, Akira
Yoshiji, Hitoshi
Ohbayashi, Chiho
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Human parvovirus (HPV) B19 is linked to a variety of clinical manifestations, such as erythema infectiosum, nonimmune hydrops fetalis, and transient aplastic anemia.
Although a few cases have shown HPVB19 infection as a possible causative agent for hepatitis-associated aplastic anemia (HAAA) in immunocompetent patients, most reported cases of HAAA following transient hepatitis did not have delayed remission.
Here we report a rare case of severe aplastic anemia following acute hepatitis with prolonged jaundice due to HPVB19 infection in a previously healthy young male.
Clinical laboratory examination assessed marked liver injury and jaundice as well as peripheral pancytopenia, and bone marrow biopsy revealed severe hypoplasia and fatty replacement.
HPVB19 infection was diagnosed by enzyme immunoassay with high titer of anti-HPVB19 immunoglobulin M antibodies.
Immunosuppressive therapy was initiated 2 months after the onset of acute hepatitis when liver injury and jaundice were improved.
Cyclosporine provided partial remission after 2 months of medication without bone marrow transplantation.
Our case suggests that HPVB19 should be considered as a hepatotropic virus and a cause of acquired aplastic anemia, including HAAA.
American Psychological Association (APA)
Furukawa, Masanori& Kaji, Kosuke& Masuda, Hiroyuki& Ozaki, Kuniaki& Asada, Shohei& Koizumi, Aritoshi…[et al.]. 2017. Severe Aplastic Anemia following Parvovirus B19-Associated Acute Hepatitis. Case Reports in Hepatology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1146089
Modern Language Association (MLA)
Furukawa, Masanori…[et al.]. Severe Aplastic Anemia following Parvovirus B19-Associated Acute Hepatitis. Case Reports in Hepatology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1146089
American Medical Association (AMA)
Furukawa, Masanori& Kaji, Kosuke& Masuda, Hiroyuki& Ozaki, Kuniaki& Asada, Shohei& Koizumi, Aritoshi…[et al.]. Severe Aplastic Anemia following Parvovirus B19-Associated Acute Hepatitis. Case Reports in Hepatology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1146089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146089