Association of Estimated Insulin Resistance with N-Terminal B-Type Natriuretic Peptide Concentration in Men with Metabolic Syndrome

Abstract EN

Background.

The diagnostic and prognostic role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure is well established.

However, additional factors may influence its concentration.

One of them is obesity, which in general is accompanied by reduced NT-proBNP levels.

However, specific data concerning metabolic syndrome (MS) are equivocal.

The aim of the present study was to evaluate the association of NT-proBNP with estimated insulin resistance (eIR) in men with MS.

Methods.

In 86 male patients with MS (78 of them hypertensive), blood pressure, anthropometric measures, NT-proBNP, creatinine, glucose, and insulin were assessed and eIR was calculated using homeostatic model assessment (HOMA-IR).

Results.

Both eIR and age were independently associated with NT-proBNP concentrations (b = 0.2248, p=0.019; b = 0.0102, p=0.049, respectively).

Blood pressure, anthropometric measures, and eGFR were not correlated with NT-proBNP.

Patients without eIR had higher NT-proBNP than those with eIR (32.2 ± 26.4 vs 21.4 ± 25.4 pg/mL, p=0.014).

The difference was even higher in the younger subgroup of patients reaching nearly 50%.

Conclusions.

Insulin resistance and, to a lesser degree, age were associated with NT-proBNP levels in men with MS.

In younger subjects with eIR, mean NT-proBNP level was lower than in corresponding healthy age males.