Association of Estimated Insulin Resistance with N-Terminal B-Type Natriuretic Peptide Concentration in Men with Metabolic Syndrome
Joint Authors
Krzesiński, Paweł
Gielerak, Grzegorz
Woźniak-Kosek, Agnieszka
Piotrowicz, Katarzyna
Piechota, Wiesław
Source
Cardiology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
The diagnostic and prognostic role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure is well established.
However, additional factors may influence its concentration.
One of them is obesity, which in general is accompanied by reduced NT-proBNP levels.
However, specific data concerning metabolic syndrome (MS) are equivocal.
The aim of the present study was to evaluate the association of NT-proBNP with estimated insulin resistance (eIR) in men with MS.
Methods.
In 86 male patients with MS (78 of them hypertensive), blood pressure, anthropometric measures, NT-proBNP, creatinine, glucose, and insulin were assessed and eIR was calculated using homeostatic model assessment (HOMA-IR).
Results.
Both eIR and age were independently associated with NT-proBNP concentrations (b = 0.2248, p=0.019; b = 0.0102, p=0.049, respectively).
Blood pressure, anthropometric measures, and eGFR were not correlated with NT-proBNP.
Patients without eIR had higher NT-proBNP than those with eIR (32.2 ± 26.4 vs 21.4 ± 25.4 pg/mL, p=0.014).
The difference was even higher in the younger subgroup of patients reaching nearly 50%.
Conclusions.
Insulin resistance and, to a lesser degree, age were associated with NT-proBNP levels in men with MS.
In younger subjects with eIR, mean NT-proBNP level was lower than in corresponding healthy age males.
American Psychological Association (APA)
Krzesiński, Paweł& Piechota, Wiesław& Piotrowicz, Katarzyna& Gielerak, Grzegorz& Woźniak-Kosek, Agnieszka. 2019. Association of Estimated Insulin Resistance with N-Terminal B-Type Natriuretic Peptide Concentration in Men with Metabolic Syndrome. Cardiology Research and Practice،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1146091
Modern Language Association (MLA)
Krzesiński, Paweł…[et al.]. Association of Estimated Insulin Resistance with N-Terminal B-Type Natriuretic Peptide Concentration in Men with Metabolic Syndrome. Cardiology Research and Practice No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1146091
American Medical Association (AMA)
Krzesiński, Paweł& Piechota, Wiesław& Piotrowicz, Katarzyna& Gielerak, Grzegorz& Woźniak-Kosek, Agnieszka. Association of Estimated Insulin Resistance with N-Terminal B-Type Natriuretic Peptide Concentration in Men with Metabolic Syndrome. Cardiology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1146091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146091