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Severe Acute Hepatitis B in HBV-Vaccinated Partner of a Patient with Multiple Myeloma Treated with Cyclophosphamide, Bortezomib, and Dexamethasone and Autologous Stem Cell Transplant
Joint Authors
Fortinsky, Kyle J.
Wong, David K.
Almaghrabi, Majed M.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Hepatitis B reactivation can occur with various forms of immunosuppression.
Cyclophosphamide, Bortezomib, and Dexamethasone (CYBOR-D) chemotherapy is commonly used for the treatment of multiple myeloma and has not been noted in guidelines to be causative in HBV reactivation.
Indeed, current guidelines do not recommend providing antiviral prophylaxis to patients with prior HBV infection.
We present a case of HBV reactivation as a result of CYBOR-D and autologous stem cell transplant which is complicated by the patient’s partner who developed acute hepatitis B.
Our case highlights the need to review the role of antiviral prophylaxis for patients undergoing treatment of multiple myeloma and also the role of ensuring immunity for close contacts of these patients who may also be at risk.
American Psychological Association (APA)
Almaghrabi, Majed M.& Fortinsky, Kyle J.& Wong, David K.. 2017. Severe Acute Hepatitis B in HBV-Vaccinated Partner of a Patient with Multiple Myeloma Treated with Cyclophosphamide, Bortezomib, and Dexamethasone and Autologous Stem Cell Transplant. Case Reports in Hepatology،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146102
Modern Language Association (MLA)
Almaghrabi, Majed M.…[et al.]. Severe Acute Hepatitis B in HBV-Vaccinated Partner of a Patient with Multiple Myeloma Treated with Cyclophosphamide, Bortezomib, and Dexamethasone and Autologous Stem Cell Transplant. Case Reports in Hepatology No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1146102
American Medical Association (AMA)
Almaghrabi, Majed M.& Fortinsky, Kyle J.& Wong, David K.. Severe Acute Hepatitis B in HBV-Vaccinated Partner of a Patient with Multiple Myeloma Treated with Cyclophosphamide, Bortezomib, and Dexamethasone and Autologous Stem Cell Transplant. Case Reports in Hepatology. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146102
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146102