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Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility
Joint Authors
Yamac, Aylin Hatice
Ismailoglu, Ziya
Ertürk, Mehmet
Celikten, Mert
Bacaksiz, Ahmet
Uysal, Omer
Kilic, U.
Source
Cardiology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
Premature myocardial infarction (PMI) is an uncommon disease, and its incidence varies between 2% and 10%, rising, depending on genetic susceptibility under the influence of lifestyle.
The purpose of this study was to investigate the association between SIRT1 single nucleotide polymorphisms (SNPs), SIRT1, and eNOS (endothelial nitric oxide synthase) protein expressions, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) in young patients with premature ST-elevation myocardial infarction (STEMI).
Methods.
Genotyping of the three single-nucleotide polymorphisms (rs7895833 A > G in the promoter region, rs7069102 C > G in intron 4, and rs2273773 C > T in exon 5) in SIRT1 gene was performed in 108 consecutive patients (87.0% were men with a mean age of 40.74 ± 3.82 years) suffering from ST-elevation myocardial infarction at the age of ≤45 and 91 control subjects.
Results.
The risk for myocardial infarction was increased by 2.31 times in carriers of CC or CG genotypes.
SIRT1 protein levels were enhanced and endothelial nitric oxide synthase levels were diminished in ST-elevation myocardial infarction patients regardless of the underlying gene variant.
There was no correlation between SIRT1 expression and the amount of endothelial nitric oxide synthase, total antioxidant status, total oxidant status, and oxidative stress index levels in patients and in the control group either.
Conclusions.
SIRT1 single-nucleotide polymorphisms were associated with premature myocardial infarction, which affected the SIRT1 and endothelial nitric oxide synthase protein expression, irrespective of the underlying SIRT1 genotype.
American Psychological Association (APA)
Yamac, Aylin Hatice& Uysal, Omer& Ismailoglu, Ziya& Ertürk, Mehmet& Celikten, Mert& Bacaksiz, Ahmet…[et al.]. 2019. Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility. Cardiology Research and Practice،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1146116
Modern Language Association (MLA)
Yamac, Aylin Hatice…[et al.]. Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility. Cardiology Research and Practice No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1146116
American Medical Association (AMA)
Yamac, Aylin Hatice& Uysal, Omer& Ismailoglu, Ziya& Ertürk, Mehmet& Celikten, Mert& Bacaksiz, Ahmet…[et al.]. Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility. Cardiology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1146116
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146116