Diphenhydramine as a Cause of Drug-Induced Liver Injury
Joint Authors
Jesudian, Arun
Namn, Yunseok
Schneider, Yecheskel
Cui, Isabelle H.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the Unites States and accounts for 10% of acute hepatitis cases.
We report the only known case of diphenhydramine-induced acute liver injury in the absence of concomitant medications.
A 28-year-old man with history of 13/14-chromosomal translocation presented with fevers, vomiting, and jaundice.
Aspartate-aminotransferase and alanine-aminotransferase levels peaked above 20,000 IU/L and 5,000 IU/L, respectively.
He developed coagulopathy but without altered mental status.
Patient reported taking up to 400 mg diphenhydramine nightly, without concomitant acetaminophen, for insomnia.
He denied taking other medications, supplements, antibiotics, and herbals.
A thorough workup of liver injury ruled out viral hepatitis (including A, B, C, and E), autoimmune, toxic, ischemic, and metabolic etiologies including Wilson’s disease.
A liver biopsy was consistent with DILI without evidence of iron or copper deposition.
Diphenhydramine was determined to be the likely culprit.
This is the first reported case of diphenhydramine-induced liver injury without concomitant use of acetaminophen.
American Psychological Association (APA)
Namn, Yunseok& Schneider, Yecheskel& Cui, Isabelle H.& Jesudian, Arun. 2017. Diphenhydramine as a Cause of Drug-Induced Liver Injury. Case Reports in Hepatology،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146122
Modern Language Association (MLA)
Namn, Yunseok…[et al.]. Diphenhydramine as a Cause of Drug-Induced Liver Injury. Case Reports in Hepatology No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1146122
American Medical Association (AMA)
Namn, Yunseok& Schneider, Yecheskel& Cui, Isabelle H.& Jesudian, Arun. Diphenhydramine as a Cause of Drug-Induced Liver Injury. Case Reports in Hepatology. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146122