Early Onset of Tenofovir-Related Fanconi Syndrome in a Child with Acute Hepatitis B: A Case Report and Systematic Review of Literature
Joint Authors
Pascale, Renato
Guardigni, Viola
Badia, Lorenzo
Volpato, Francesca
Viale, Pierluigi
Verucchi, Gabriella
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Tenofovir disoproxil fumarate- (TDF-) related nephropathy is known to be a long-term complication of this drug, more commonly observed in HIV-infected patients, but occurring also in hepatitis B.
Cases of Fanconi Syndrome associated with TDF have been reported in adult patients, usually as a long-term complication of chronic hepatitis B treatment.
We present here a case of a 12-year-old male developing a severe acute HBV hepatitis treated with TDF.
The patient achieved an early virological and biochemical response, but with a subsequent onset of proximal renal tubular damage, consistent with Fanconi Syndrome.
After withdrawing this drug and switching to Entecavir, a complete resolution of tubulopathy and, after 6 months, a complete HBsAg seroconversion occurred.
To our knowledge, this is the first report of an early renal injury due to TDF-therapy in a pediatric patient treated for acute hepatitis B.
American Psychological Association (APA)
Pascale, Renato& Guardigni, Viola& Badia, Lorenzo& Volpato, Francesca& Viale, Pierluigi& Verucchi, Gabriella. 2017. Early Onset of Tenofovir-Related Fanconi Syndrome in a Child with Acute Hepatitis B: A Case Report and Systematic Review of Literature. Case Reports in Hepatology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1146125
Modern Language Association (MLA)
Pascale, Renato…[et al.]. Early Onset of Tenofovir-Related Fanconi Syndrome in a Child with Acute Hepatitis B: A Case Report and Systematic Review of Literature. Case Reports in Hepatology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1146125
American Medical Association (AMA)
Pascale, Renato& Guardigni, Viola& Badia, Lorenzo& Volpato, Francesca& Viale, Pierluigi& Verucchi, Gabriella. Early Onset of Tenofovir-Related Fanconi Syndrome in a Child with Acute Hepatitis B: A Case Report and Systematic Review of Literature. Case Reports in Hepatology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1146125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146125