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Safety of Sofosbuvir and Ribavirin Combination Therapy in a Patient Who Developed Anemia due to Ribavirin
Joint Authors
Toyota, Jouji
Suii, Hirokazu
Ozeki, Itaru
Tatsumi, Ryoji
Yamaguchi, Masakatsu
Kimura, Mutsuumi
Arakawa, Tomohiro
Nakajima, Tomoaki
Kuwata, Yasuaki
Ohmura, Takumi
Hige, Shuhei
Karino, Yoshiyasu
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-10
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Interferon (IFN) and ribavirin (RBV) combination therapy was previously the standard of care for treatment of hepatitis C virus (HCV) genotype 2 infection.
But, it often induced hemolytic anemia.
In 2014, sofosbuvir (SOF) was approved for the treatment of chronic HCV genotype 2 in Japan.
SOF/RBV therapy is more effective against genotype 2 than IFN/RBV therapy.
We report a case of a 74-year-old woman with chronic HCV genotype 2b infection.
She received five treatments including RBV and IFN therapy before SOF was approved and all of them were ineffective.
Therapies that included RBV induced severe anemia and led to discontinuation of treatment.
With pegylated IFN/RBV therapy, the maximum change in hemoglobin (Hb) from baseline was −3.7 g/dL.
However, SOF/RBV therapy was effective and she achieved sustained virologic response (SVR) with a maximum change in Hb from baseline of only −1.2 g/dL.
We also found reticulocyte count was very low during treatment in this case and speculate it was one of the reasons that she developed hemolytic anemia with RBV.
In conclusion, SOF/RBV therapy is effective and allowed the patient to achieve SVR.
An SOF/RBV regimen is safe and effective for patients who have or are at risk of anemia induced by RBV.
American Psychological Association (APA)
Suii, Hirokazu& Ozeki, Itaru& Tatsumi, Ryoji& Yamaguchi, Masakatsu& Kimura, Mutsuumi& Arakawa, Tomohiro…[et al.]. 2017. Safety of Sofosbuvir and Ribavirin Combination Therapy in a Patient Who Developed Anemia due to Ribavirin. Case Reports in Hepatology،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146143
Modern Language Association (MLA)
Suii, Hirokazu…[et al.]. Safety of Sofosbuvir and Ribavirin Combination Therapy in a Patient Who Developed Anemia due to Ribavirin. Case Reports in Hepatology No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1146143
American Medical Association (AMA)
Suii, Hirokazu& Ozeki, Itaru& Tatsumi, Ryoji& Yamaguchi, Masakatsu& Kimura, Mutsuumi& Arakawa, Tomohiro…[et al.]. Safety of Sofosbuvir and Ribavirin Combination Therapy in a Patient Who Developed Anemia due to Ribavirin. Case Reports in Hepatology. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146143