Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the Literature
Joint Authors
Wei, Eric X.
Jordan, Paul
Boktor, Moheb
Knowles, Kurt
Bienvenu, John
Seth, Abhishek
Morris, James
Manas, Kenneth
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-03
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Synthetic cannabinoids (SCs) abuse is on the rise because they are easily obtained over the counter; they are potent psychoactive compounds and routine drug testing does not detect them.
As their abuse is on the rise, so are their detrimental side effects; however, the occurrence of acute hepatitis due to SCs abuse has been reported only once before.
In this case, testing revealed that the patient was also heterozygous for alpha-1-antitrypsin (A-1-AT) with the phenotype of PI⁎EM.
This mutant phenotype has never been reported as a cause of A-1-AT disease and the abuse of SCs in a patient with this phenotype has also never been reported.
This case illustrates the possible need to expand routine drug testing for SCs and consider A-1-AT phenotyping in certain clinical scenarios.
American Psychological Association (APA)
Knowles, Kurt& Wei, Eric X.& Seth, Abhishek& Bienvenu, John& Morris, James& Manas, Kenneth…[et al.]. 2017. Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the Literature. Case Reports in Hepatology،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1146150
Modern Language Association (MLA)
Knowles, Kurt…[et al.]. Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the Literature. Case Reports in Hepatology No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1146150
American Medical Association (AMA)
Knowles, Kurt& Wei, Eric X.& Seth, Abhishek& Bienvenu, John& Morris, James& Manas, Kenneth…[et al.]. Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the Literature. Case Reports in Hepatology. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1146150
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146150