Pembrolizumab-Induced Mobitz Type 2 Second-Degree Atrioventricular Block
Joint Authors
Khan, Alisha
Riaz, Sana
Carhart, Robert
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Pembrolizumab is a monoclonal antibody directed towards programmed cell death protein 1 (PD-1) and is an antineoplastic drug which has a growing variety of oncologic uses.
Pembrolizumab is commonly associated with immune-related adverse events (IRAEs) but is infrequently noted to cause cardiotoxicities such as myocarditis, arrhythmias, and heart failure.
The following case report illustrates the clinical course of a 67-year-old female patient with stage IV non-small-cell lung cancer who developed Mobitz type 2 second-degree atrioventricular block three weeks after receiving her first infusion of pembrolizumab.
Within a few hours of presentation, she progressed to symptomatic complete heart block requiring emergent placement of a temporary transvenous pacemaker.
The article further discusses proposed mechanisms to explain IRAEs and management of IRAEs.
We conclude by recommending a higher degree of caution and awareness among all physicians when treating patients on immunotherapy and a multidisciplinary approach when considering resumption of immune checkpoint inhibitor therapy.
American Psychological Association (APA)
Khan, Alisha& Riaz, Sana& Carhart, Robert. 2020. Pembrolizumab-Induced Mobitz Type 2 Second-Degree Atrioventricular Block. Case Reports in Cardiology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1146169
Modern Language Association (MLA)
Khan, Alisha…[et al.]. Pembrolizumab-Induced Mobitz Type 2 Second-Degree Atrioventricular Block. Case Reports in Cardiology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1146169
American Medical Association (AMA)
Khan, Alisha& Riaz, Sana& Carhart, Robert. Pembrolizumab-Induced Mobitz Type 2 Second-Degree Atrioventricular Block. Case Reports in Cardiology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1146169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146169