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Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country
Joint Authors
Parajuli, Narayan Prasad
Joshi, Govardhan
Khanal, Puspa Raj
Bhetwal, Anjeela
Shakya, Shreena
Pandit, Roshan
Pardhe, Bashu Dev
Shakya, Jyotsna
Shrestha, Sumesh Shreekhanda
Source
Case Reports in Infectious Diseases
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Shigellosis is an acute infectious disease characterized as severe bloody diarrhea (dysentery) and is accountable for a significant burden of morbidity and mortality especially in children under the age of 5 years.
Antimicrobial therapy is required in the cases of severe dysentery associated with Shigella.
However, emergence of multidrug resistant (MDR) strains of Shigella spp.
over the last two decades has restricted the use of common therapeutic antimicrobials.
In MDR strains, the third-generation cephalosporins have been used for the treatment, but, unfortunately, emerging reports of enzyme mediated β-lactam resistance among Shigella isolates from various parts of the world have greatly compromised the therapy of pediatric dysentery.
In Nepal, drug resistant strains of Shigella spp.
have been reported, but MDR and extended spectrum β-lactamase (ESBL) producing strains were previously unknown.
Here, we report two Shigella flexneri isolates harboring ESBL genotype-CTX-M associated with acute dysentery in two siblings which were presented and treated in a tertiary care teaching hospital of Kathmandu, Nepal.
American Psychological Association (APA)
Parajuli, Narayan Prasad& Joshi, Govardhan& Pardhe, Bashu Dev& Shakya, Jyotsna& Bhetwal, Anjeela& Shakya, Shreena…[et al.]. 2017. Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country. Case Reports in Infectious Diseases،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1146235
Modern Language Association (MLA)
Parajuli, Narayan Prasad…[et al.]. Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country. Case Reports in Infectious Diseases No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1146235
American Medical Association (AMA)
Parajuli, Narayan Prasad& Joshi, Govardhan& Pardhe, Bashu Dev& Shakya, Jyotsna& Bhetwal, Anjeela& Shakya, Shreena…[et al.]. Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country. Case Reports in Infectious Diseases. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1146235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146235