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The Use of Exogenous Lung Surfactant (Poractant Alfa) in Acute Respiratory Failure by Drowning
Joint Authors
Scozzafava, Annamaria
Verre, Mario
Giglio, Anna Maria
Pezzi, Mario
Givigliano, Francesco
Perrone, Ottorino
Maglio, Pietro
Casella, Patrizia
Voci, Carlo Pietro
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Drowning is an acute respiratory failure as a result from immersion or submersion of the airways in a liquid medium (predominantly water).
Inhalation of water causes severe lung damage due to the destruction of pulmonary surfactant, resulting in decreased lung elasticity, alveolar collapse, alteration of ventilation-perfusion ratio, intrapulmonary blood shunting, hypoxia, acute lung injury, and Acute Respiratory Distress Syndrome (ARDS).
Poractant alfa (Curosurf®), a natural surfactant effective in the treatment of newborn respiratory distress, has been used in various forms of ARDS, but in drowning syndromes, experience is still poor.
We describe a series of nine clinical cases of drowning, six adults and three children, treated in our Intensive Care Unit (ICU) with endobronchial administration of poractant alfa.
After 24 and 48 hours of administration in all cases, there was an improvement in arterial blood gas analysis (ABG) parameters and imaging.
All patients were discharged without clinical consequences.
American Psychological Association (APA)
Pezzi, Mario& Givigliano, Francesco& Perrone, Ottorino& Scozzafava, Annamaria& Maglio, Pietro& Casella, Patrizia…[et al.]. 2020. The Use of Exogenous Lung Surfactant (Poractant Alfa) in Acute Respiratory Failure by Drowning. Case Reports in Critical Care،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1146366
Modern Language Association (MLA)
Pezzi, Mario…[et al.]. The Use of Exogenous Lung Surfactant (Poractant Alfa) in Acute Respiratory Failure by Drowning. Case Reports in Critical Care No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1146366
American Medical Association (AMA)
Pezzi, Mario& Givigliano, Francesco& Perrone, Ottorino& Scozzafava, Annamaria& Maglio, Pietro& Casella, Patrizia…[et al.]. The Use of Exogenous Lung Surfactant (Poractant Alfa) in Acute Respiratory Failure by Drowning. Case Reports in Critical Care. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1146366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146366