A Case of Fulminant Meningococcemia: It Is All in the Complement
Joint Authors
Hawkins, Kellie L.
Hoffman, Mariah
Okuyama, Sonia
Rowan, Sarah E.
Source
Case Reports in Infectious Diseases
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-20
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Eculizumab is a novel monoclonal antibody that inhibits complement-mediated hemolysis in patients with paroxysmal nocturnal hemoglobinuria (PNH).
Complement deficiency is a well-known risk factor for meningococcal infection.
We describe a case of a young patient with PNH treated with eculizumab who presented with a life-threatening case of nongroupable meningococcemia.
As this new biologic agent becomes more widely prescribed, providers should be aware of the increased risk of meningococcemia.
In addition to vaccination, providers may consider the use of oral penicillin for antibiotic prophylaxis against Neisseria meningitidis in these cases of functional complement deficiency.
American Psychological Association (APA)
Hawkins, Kellie L.& Hoffman, Mariah& Okuyama, Sonia& Rowan, Sarah E.. 2017. A Case of Fulminant Meningococcemia: It Is All in the Complement. Case Reports in Infectious Diseases،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1146385
Modern Language Association (MLA)
Hawkins, Kellie L.…[et al.]. A Case of Fulminant Meningococcemia: It Is All in the Complement. Case Reports in Infectious Diseases No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1146385
American Medical Association (AMA)
Hawkins, Kellie L.& Hoffman, Mariah& Okuyama, Sonia& Rowan, Sarah E.. A Case of Fulminant Meningococcemia: It Is All in the Complement. Case Reports in Infectious Diseases. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1146385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146385