Sinusoidal Obstruction Syndrome (SOS) in Multiple Myeloma with Renal Failure
Joint Authors
Shah, Urvi A.
Viswanathan, Sengottuvel
Agarwal, Beamon
Shastri, Aditi
Mantzaris, Ioannis
Janakiram, Murali
Kornblum, Noah
Braunschweig, Ira
Verma, Amit
Shi, Yang
Reinus, John
Derman, Olga
Source
Case Reports in Oncological Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
SOS is a rare complication of stem cell transplantation and has significant morbidity and mortality.
We present three cases of SOS and highlight underlying risk factors for its development, such as impaired clearance of alkylating agents (especially melphalan) in patients with renal failure and prolonged infection.
Although, melphalan and cyclophosphamide cause SOS less commonly than alkylating agents such as busulfan, physicians must use caution when administering these drugs to patients with underlying comorbidities such as renal failure that may increase the likelihood of development of SOS.
This is due to unpredictable pharmacokinetics in patients with renal failure and therefore close drug monitoring is required.
With the recent FDA approval of defibrotide in 2016, outcomes of SOS have improved and physician awareness is important for prompt diagnosis and treatment.
American Psychological Association (APA)
Shah, Urvi A.& Viswanathan, Sengottuvel& Agarwal, Beamon& Shastri, Aditi& Mantzaris, Ioannis& Janakiram, Murali…[et al.]. 2018. Sinusoidal Obstruction Syndrome (SOS) in Multiple Myeloma with Renal Failure. Case Reports in Oncological Medicine،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1146430
Modern Language Association (MLA)
Shah, Urvi A.…[et al.]. Sinusoidal Obstruction Syndrome (SOS) in Multiple Myeloma with Renal Failure. Case Reports in Oncological Medicine No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1146430
American Medical Association (AMA)
Shah, Urvi A.& Viswanathan, Sengottuvel& Agarwal, Beamon& Shastri, Aditi& Mantzaris, Ioannis& Janakiram, Murali…[et al.]. Sinusoidal Obstruction Syndrome (SOS) in Multiple Myeloma with Renal Failure. Case Reports in Oncological Medicine. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1146430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146430