A Case of Lenvatinib-Induced Focal Segmental Glomerulosclerosis (FSGS)‎ in Metastatic Medullary Thyroid Cancer

Abstract EN

We describe a case of lenvatinib (E7080) associated focal segmental glomerulosclerosis (FSGS) encountered during the treatment of metastatic medullary thyroid cancer.

Proteinuria is a relatively common side effect of VEGF-targeted treatments and can occasionally result in treatment discontinuation.

Here, we describe a patient who developed secondary FSGS necessitating discontinuation of treatment at first but who was subsequently rechallenged with anti-VEGF-targeted treatment without recurrence of proteinuria.

Lenvatinib was a novel experimental agent at the time the treatment took place; however, its recent licensing for the treatment of thyroid malignancies in the UK makes reporting of these adverse effects all the more important now.