Renal Tubular Acidosis an Adverse Effect of PD-1 Inhibitor Immunotherapy
Joint Authors
Odaimi, Marcel
El Bitar, Sandy
Weerasinghe, Chanudi
El-Charabaty, Elie
Source
Case Reports in Oncological Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Immune checkpoint blockade therapy is gaining popularity among oncologists for treatment of solid and hematologic malignancies.
The widespread use of these agents resulted in increasing incidence of renal immune-related adverse events.
Reported renal toxicity described so far includes acute interstitial nephritis, minimal change disease, and immune complex glomerulonephritis.
We report the case of a 79-year-old female with metastatic non-small cell lung cancer on anti-PD-1 therapy nivolumab.
After the 4th administration of nivolumab, the treatment course was complicated with normal anion gap metabolic acidosis.
Urine and blood studies were in favor of distal renal tubular acidosis (RTA).
Following a negative workup for an underlying etiology, immunotherapy-induced RTA was suspected.
Withholding of the offending agent and initiation of steroid therapy resulted in adequate response.
The present report provides the first presentation of RTA as a renal immune-related adverse event secondary to nivolumab.
Nephrologists and oncologists should be familiar with potentially life-threatening renal side effects induced by immune checkpoint inhibitors.
American Psychological Association (APA)
El Bitar, Sandy& Weerasinghe, Chanudi& El-Charabaty, Elie& Odaimi, Marcel. 2018. Renal Tubular Acidosis an Adverse Effect of PD-1 Inhibitor Immunotherapy. Case Reports in Oncological Medicine،Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1146625
Modern Language Association (MLA)
El Bitar, Sandy…[et al.]. Renal Tubular Acidosis an Adverse Effect of PD-1 Inhibitor Immunotherapy. Case Reports in Oncological Medicine No. 2018 (2018), pp.1-3.
https://search.emarefa.net/detail/BIM-1146625
American Medical Association (AMA)
El Bitar, Sandy& Weerasinghe, Chanudi& El-Charabaty, Elie& Odaimi, Marcel. Renal Tubular Acidosis an Adverse Effect of PD-1 Inhibitor Immunotherapy. Case Reports in Oncological Medicine. 2018. Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1146625
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146625