![](/images/graphics-bg.png)
A Novel Adverse Event Associated with Olaparib Therapy in a Patient with Metastatic Breast Cancer
Joint Authors
Wheelden, Megan
Cream, Leah
Sivik, Jeffrey
Robson, Mark
Source
Case Reports in Oncological Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Olaparib was first FDA approved for use in women with advanced ovarian cancer and germline BRCA mutations.
Based on the results of subsequent research, the use of this drug has been expanded to patients with metastatic breast cancer with germline BRCA mutation.
With the use of a relatively new medication and a larger patient population eligible for therapy, monitoring for novel adverse events associated with therapy is important.
This case represents a patient with metastatic breast cancer and germline BRCA2 mutation who developed erythema nodosum after initiation of therapy with olaparib capsules.
Her characteristic rash appeared shortly after starting olaparib and recurred after restarting olaparib an additional two times.
She was treated with short courses of prednisone therapy with or without holding olaparib with resolution of her rash.
The patient was later restarted on olaparib capsules 200 mg twice daily, and she more recently has been maintained on olaparib tablets 300 mg twice daily.
On both regimens, the patient experienced only attenuated episodes of erythema nodosum that have not required cessation of therapy or steroid therapy.
American Psychological Association (APA)
Wheelden, Megan& Cream, Leah& Sivik, Jeffrey& Robson, Mark. 2018. A Novel Adverse Event Associated with Olaparib Therapy in a Patient with Metastatic Breast Cancer. Case Reports in Oncological Medicine،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1146673
Modern Language Association (MLA)
Wheelden, Megan…[et al.]. A Novel Adverse Event Associated with Olaparib Therapy in a Patient with Metastatic Breast Cancer. Case Reports in Oncological Medicine No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1146673
American Medical Association (AMA)
Wheelden, Megan& Cream, Leah& Sivik, Jeffrey& Robson, Mark. A Novel Adverse Event Associated with Olaparib Therapy in a Patient with Metastatic Breast Cancer. Case Reports in Oncological Medicine. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1146673
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146673