Serum Cytokine Profile in a Patient Diagnosed with Dysferlinopathy
Joint Authors
Khaiboullina, Svetlana F.
Martynova, Ekaterina V.
Deev, R. V.
Isaev, A. A.
Rizvanov, Albert A.
Bardakov, Sergey N.
Mavlikeev, Mikhail O.
Yakovlev, Ivan A.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Limb-girdle muscular dystrophy type 2 (LGMD2B) is a mild form of dysferlinopathy, characterized by limb weakness and wasting.
It is an autosomal recessive disease, with currently 140 mutations in the LGMD2B gene identified.
Lack of functional dysferlin inhibits muscle fiber regeneration in voluntary muscles, the main pathological finding in LGMD2B patients.
However, the immune system has been suggested to contribute to muscle cell death and tissue regeneration.
Serum levels of 27 cytokines were evaluated in a dysferlinopathy patient.
Levels of 8 cytokines differed in patient serum compared to controls.
Five cytokines (IL-10, IL-17, CCL2, CXCL10, and G-CSF) were higher while 3 were lower in the patient than in controls (IL-2, IL-8, and CCL11).
Together, these data on serum cytokine profile of this dysferlinopathy patient suggest immune response activation, which could explain leukocyte infiltration in the muscle tissue.
American Psychological Association (APA)
Khaiboullina, Svetlana F.& Martynova, Ekaterina V.& Bardakov, Sergey N.& Mavlikeev, Mikhail O.& Yakovlev, Ivan A.& Isaev, A. A.…[et al.]. 2017. Serum Cytokine Profile in a Patient Diagnosed with Dysferlinopathy. Case Reports in Medicine،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1146684
Modern Language Association (MLA)
Khaiboullina, Svetlana F.…[et al.]. Serum Cytokine Profile in a Patient Diagnosed with Dysferlinopathy. Case Reports in Medicine No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1146684
American Medical Association (AMA)
Khaiboullina, Svetlana F.& Martynova, Ekaterina V.& Bardakov, Sergey N.& Mavlikeev, Mikhail O.& Yakovlev, Ivan A.& Isaev, A. A.…[et al.]. Serum Cytokine Profile in a Patient Diagnosed with Dysferlinopathy. Case Reports in Medicine. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1146684
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146684