Drug Induced Pneumonitis Secondary to Treatment with ParitaprevirRitonavirOmbitasvir and Dasabuvir (VIEKIRA PAK®) for Chronic Hepatitis C: Case Report of an Unexpected Life-Threatening Adverse Reaction
Joint Authors
Wu, Shih Yea Sylvia
Faire, Bridget
Gane, Edward
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
VIEKIRA PAK (ritonavir-boosted paritaprevir/ombitasvir and dasabuvir) is an approved treatment for compensated patients with genotype 1 (GT1) chronic hepatitis C virus (HCV) infection.
This oral regimen has minimal adverse effects and is well tolerated.
Cure rates are 97% in patients infected with HCV GT 1a and 99% in those with HCV GT 1b.
We report the first case of life-threatening allergic pneumonitis associated with VIEKIRA PAK.
This unexpected serious adverse event occurred in a 68-year-old Chinese female with genotype 1b chronic hepatitis C and Child-Pugh A cirrhosis.
One week into treatment with VIEKIRA PAK without ribavirin, she was admitted to hospital with respiratory distress and acute kidney injury requiring intensive care input.
She was initially diagnosed with community acquired pneumonia and improved promptly with intravenous antibiotics and supported care.
No bacterial or viral pathogens were cultured.
Following complete recovery, she recommenced VIEKIRA PAK but represented 5 days later with more rapidly progressive respiratory failure, requiring intubation and ventilation, inotropic support, and haemodialysis.
The final diagnosis was drug induced pneumonitis.
American Psychological Association (APA)
Wu, Shih Yea Sylvia& Faire, Bridget& Gane, Edward. 2017. Drug Induced Pneumonitis Secondary to Treatment with ParitaprevirRitonavirOmbitasvir and Dasabuvir (VIEKIRA PAK®) for Chronic Hepatitis C: Case Report of an Unexpected Life-Threatening Adverse Reaction. Case Reports in Medicine،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1146748
Modern Language Association (MLA)
Wu, Shih Yea Sylvia…[et al.]. Drug Induced Pneumonitis Secondary to Treatment with ParitaprevirRitonavirOmbitasvir and Dasabuvir (VIEKIRA PAK®) for Chronic Hepatitis C: Case Report of an Unexpected Life-Threatening Adverse Reaction. Case Reports in Medicine No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1146748
American Medical Association (AMA)
Wu, Shih Yea Sylvia& Faire, Bridget& Gane, Edward. Drug Induced Pneumonitis Secondary to Treatment with ParitaprevirRitonavirOmbitasvir and Dasabuvir (VIEKIRA PAK®) for Chronic Hepatitis C: Case Report of an Unexpected Life-Threatening Adverse Reaction. Case Reports in Medicine. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1146748
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146748