Diagnosis of Vitreoretinal Aspergillosis with Transvitreal Retinochoroidal Biopsy
Joint Authors
Li, Weiye
Peddada, Krishi
Khan, Nida M.
Rubin, Jascha
Zakaryan, Haykanush
Liu, Yaobin
Popnikolov, Nikolay
Sangani, Roshun
Source
Case Reports in Ophthalmological Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-02
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Diagnosing culture-proven endophthalmitis is complicated by the insufficient yield of intraocular samples and the variety of etiologies which mimic true endophthalmitis.
In cases of impending vision loss where vitreous biopsy cannot provide a definitive diagnosis, transvitreal retinochoroidal biopsy can be an effective next step.
Our case is a 48-year-old male with B-cell acute lymphoblastic leukemia that presented with counting fingers vision, redness, and tearing of the left eye.
Exam showed cell and flare with hypopyon as well as dense vitritis.
The patient underwent diagnostic pars plana vitrectomy and vitreous culture was negative at the time.
Flow cytometry demonstrated no malignant cells.
However, the patient’s vision and mental status continued to clinically decline despite being started on intravitreal and systemic antibiotic and antifungal therapy.
Neuroimaging revealed rim-enhancing brain lesions.
Transvitreal retinochoroidal biopsy was performed in an elevated area of the retina.
The biopsy helped rule out malignancy and showed acute-angle, septate, branching hyphae characteristic of Aspergillus fumigatus.
Ultimately, the vitreous biopsy, cultures, and a biopsy from the left frontal lobe brain abscess all confirmed this diagnosis as well.
Transvitreal retinochoroidal biopsy can play a role in the diagnosis of a case of posterior uveitis and can be particularly effective in diagnosing a fungal endophthalmitis.
American Psychological Association (APA)
Peddada, Krishi& Khan, Nida M.& Rubin, Jascha& Zakaryan, Haykanush& Liu, Yaobin& Popnikolov, Nikolay…[et al.]. 2018. Diagnosis of Vitreoretinal Aspergillosis with Transvitreal Retinochoroidal Biopsy. Case Reports in Ophthalmological Medicine،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1146821
Modern Language Association (MLA)
Peddada, Krishi…[et al.]. Diagnosis of Vitreoretinal Aspergillosis with Transvitreal Retinochoroidal Biopsy. Case Reports in Ophthalmological Medicine No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1146821
American Medical Association (AMA)
Peddada, Krishi& Khan, Nida M.& Rubin, Jascha& Zakaryan, Haykanush& Liu, Yaobin& Popnikolov, Nikolay…[et al.]. Diagnosis of Vitreoretinal Aspergillosis with Transvitreal Retinochoroidal Biopsy. Case Reports in Ophthalmological Medicine. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1146821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146821