Expression of La Ribonucleoprotein Domain Family Member 4B (LARP4B) in Liver Cancer and Their Clinical and Prognostic Significance
Joint Authors
Jiao, Yan
Li, Yanqing
Li, Yang
Liu, Yanan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background and Objective.
Liver cancer is a common malignant tumor with few poor diagnostic and prognostic markers, which greatly shortens the potential life span of patients.
The RNA-binding protein la ribonucleoprotein 4B (LARP4B) has a la motif (lam) that is important in the process of cancer.
We aimed to explore the role of LARP4B in the diagnosis and prognosis of liver cancer.
Methods.
The Cancer Genome Atlas (TCGA) database was searched to detect LARP4B gene expression in liver cancer.
The clinical relevance and diagnostic ability of LARP4B were evaluated by a chi-squared test and a receiver operating characteristic (ROC) curve, respectively.
Survival and risk factors of patients with liver cancer were assessed by survival analysis and univariate/multivariate Cox regression model.
Additionally, we carried out gene set enrichment analysis (GSEA) to identify LARP4B-related signaling pathways in liver cancer.
Results.
LARP4B mRNA was highly expressed in liver cancer tissues and was correlated with survival status.
The chi-squared test showed that LARP4B had clinical relevance, while ROC curves showed that LARP4B had good diagnostic ability.
Survival analysis showed that liver cancer patients with high LARP4B expression had shorter overall/relapse-free survival.
The univariate/multivariate Cox regression model indicated that high LARP4B expression may be an independent risk factor for the prognosis of liver cancer patients.
Finally, we found that genes involved in the G2M checkpoint, E2F targets, and mitotic spindle were differentially enriched in the high LARP4B-expression phenotype.
Conclusions.
LARP4B is a potential independent biomarker for diagnosis and prognosis in liver cancer patients.
American Psychological Association (APA)
Li, Yanqing& Jiao, Yan& Li, Yang& Liu, Yanan. 2019. Expression of La Ribonucleoprotein Domain Family Member 4B (LARP4B) in Liver Cancer and Their Clinical and Prognostic Significance. Disease Markers،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1146878
Modern Language Association (MLA)
Li, Yanqing…[et al.]. Expression of La Ribonucleoprotein Domain Family Member 4B (LARP4B) in Liver Cancer and Their Clinical and Prognostic Significance. Disease Markers No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1146878
American Medical Association (AMA)
Li, Yanqing& Jiao, Yan& Li, Yang& Liu, Yanan. Expression of La Ribonucleoprotein Domain Family Member 4B (LARP4B) in Liver Cancer and Their Clinical and Prognostic Significance. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1146878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146878